Evidence map›Paper›PMID 27909217›Full record

ArticleHaematologica2017

The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells.

Martine van Keimpema, Leonie J Grüneberg, Esther J M Schilder-Tol, Monique E C M Oud, Esther A Beuling, Paul J Hensbergen, Johann de Jong, Steven T Pals, Marcel Spaargaren

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Martine van KeimpemaDepartment of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Leiden University Medical Center, Amsterdam, The Netherlands.
Leonie J GrünebergDepartment of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Leiden University Medical Center, Amsterdam, The Netherlands.
Esther J M Schilder-TolDepartment of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Leiden University Medical Center, Amsterdam, The Netherlands.
Monique E C M OudDepartment of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Leiden University Medical Center, Amsterdam, The Netherlands.
Esther A BeulingDepartment of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Leiden University Medical Center, Amsterdam, The Netherlands.
Paul J HensbergenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Amsterdam, The Netherlands.
Johann de JongDivision of Molecular Carcinogenesis, Netherlands Cancer institute, Amsterdam, The Netherlands.
Steven T PalsDepartment of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Leiden University Medical Center, Amsterdam, The Netherlands.
Marcel SpaargarenDepartment of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Leiden University Medical Center, Amsterdam, The Netherlands marcel.spaargaren@amc.uva.nl.
Leiden University Medical Center · NLAcademic Medical Center · NLNetherlands Metabolomics Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The forkhead transcription factor FOXP1 is generally regarded as an oncogene in activated B cell-like diffuse large B-cell lymphoma. Previous studies have suggested that a small isoform of FOXP1 rather than full-length FOXP1, may possess this oncogenic activity. Corroborating those studies, we herein show that activated B cell-like diffuse large B-cell lymphoma cell lines and primary activated B cell-like diffuse large B-cell lymphoma cells predominantly express a small FOXP1 isoform, and that the 5'-end of the

Indexed as

Gene Expression Regulation, NeoplasticTranscriptional ActivationAlternative SplicingAmino Acid SequenceAnimalsB-LymphocytesCaspase 3Caspase 7Cell CycleCell DifferentiationCell Line, TumorCell ProliferationCell SurvivalDisease Models, AnimalForkhead Transcription FactorsHumansCaspase 3Caspase 7Forkhead Transcription FactorsFOXP1 protein, humanProtein IsoformsRepressor Proteins

Identifiers

PMID27909217
PMCPMC5394978
OpenAlexW2557948187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.