ArticleCerebral cortex (New York, N.Y. : 1991)2017
Association of Protein Distribution and Gene Expression Revealed by PET and Post-Mortem Quantification in the Serotonergic System of the Human Brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Association of CNR1 gene and cannabinoid 1 receptor protein in the human brain.Journal of neuroscience research · 2023Pooled it
- Organization of neuropeptide systems in the human brain.Nature neuroscience · 2026Article
- Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics.Nature communications · 2025Article
- Dynamic Model of Serotonin Presynapse and Its Application to Suicide Attempt in Patients with Bipolar Disorder.International journal of molecular sciences · 2025Article
- Benchmarking macaque brain gene expression for horizontal and vertical translation.Science advances · 2025Article
- Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human brain.European journal of nuclear medicine and molecular imaging · 2023Article
- Effect of MAOA DNA Methylation on Human in Vivo Protein Expression Measured by [11C]harmine Positron Emission Tomography.The international journal of neuropsychopharmacology · 2023Article
- Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI.Human brain mapping · 2022Article
- Serotonin transporter in the temporal lobe, hippocampus and amygdala in SUDEP.Brain pathology (Zurich, Switzerland) · 2022Article
- Structural Features of the Human Connectome That Facilitate the Switching of Brain Dynamics via Noradrenergic Neuromodulation.Frontiers in computational neuroscience · 2021Article
- Association of dopamine DNeuroImage · 2020Article
- Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders.Nature reviews. Neuroscience · 2020Review
- Topologically Guided Prioritization of Candidate Gene Transcripts Coexpressed with the 5-HT1A Receptor by Combining In Vivo PET and Allen Human Brain Atlas Data.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- MAOA-VNTR genotype affects structural and functional connectivity in distributed brain networks.Human brain mapping · 2019Article
- Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment.Journal of movement disorders · 2019Article
- Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regional differences in posttranscriptional mechanisms may influence in vivo protein densities. The association of positron emission tomography (PET) imaging data from 112 healthy controls and gene expression values from the Allen Human Brain Atlas, based on post-mortem brains, was investigated for key serotonergic proteins. PET binding values and gene expression intensities were correlated for the main inhibitory (5-HT1A) and excitatory (5-HT2A) serotonin receptor, the serotonin transporter (SERT) as well as monoamine oxidase-A (MAO-A), using Spearman's correlation coefficients (rs) in a voxel-wise and region-wise analysis. Correlations indicated a strong linear relationship between gene and protein expression for both the 5-HT1A (voxel-wise rs = 0.71; region-wise rs = 0.93) and the 5-HT2A receptor (rs = 0.66; 0.75), but only a weak association for MAO-A (rs = 0.26; 0.66) and no clear correlation for SERT (rs = 0.17; 0.29). Additionally, region-wise correlations were performed using mRNA expression from the HBT, yielding comparable results (5-HT1Ars = 0.82; 5-HT2Ars = 0.88; MAO-A rs = 0.50; SERT rs = -0.01). The SERT and MAO-A appear to be regulated in a region-specific manner across the whole brain. In contrast, the serotonin-1A and -2A receptors are presumably targeted by common posttranscriptional processes similar in all brain areas suggesting the applicability of mRNA expression as surrogate parameter for density of these proteins.
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