Evidence map›Paper›PMID 27908282›Full record

Trial reportBMC cancer2016

Role of geriatric intervention in the treatment of older patients with cancer: rationale and design of a phase III multicenter trial.

Pierre Soubeyran, Catherine Terret, Carine Bellera, Franck Bonnetain, Olivier Saint Jean, Angéline Galvin, Camille Chakiba, Marie-Dominique Zwolakowski, Simone Mathoulin-Pélissier, Muriel Rainfray

Registry-linked trialAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02704832 (Role of Geriatric Intervention in Treatment of Older Patients With Cancer), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02704832 nacompletednot on this map

Role of Geriatric Intervention in Treatment of Older Patients With Cancer : a Phase III Randomized Study (PREPARE)

TypeinterventionalSponsorInstitut BergoniéRan2016 to 2025Enrolled792ConditionsBreast Cancer, Colorectal Cancer, Lung Cancer, Prostate CancerArmsGeriatrician Intervention
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Personalised treatment for older adults with cancer: The role of frailty assessment.Technical innovations & patient support in radiation oncology · 2020
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pierre SoubeyranDepartment of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France. p.Soubeyran@bordeaux.unicancer.fr.
Catherine TerretDepartment of Medical Oncology, Centre Léon Bérard, Regional Comprehensive Cancer Center, Claude-Bernard Lyon-1 University, Lyon, France.
Carine BelleraClinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France.
Franck BonnetainMethodology and Quality of life in Oncology Unit, EA3181. CHU Besançon, F-25000, Besançon, France.
Olivier Saint JeanGeriatric service, Georges Pompidou European Hospital, Paris, France.
Angéline GalvinFrench National Cancer Institute (INCa) Integrated Cancer Research Site (SIRIC), Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France.
Camille ChakibaDepartment of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France.
Marie-Dominique ZwolakowskiDepartment of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France.
Simone Mathoulin-PélissierUniversity of Bordeaux, F-33000, Bordeaux, France.
Muriel RainfrayUniversity of Bordeaux, F-33000, Bordeaux, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the general geriatric population, programs linking geriatric evaluation with interventions are effective for improving functional status and survival of the patients. Whether or not these interventions improve health related quality of life (HRQoL) or overall survival (OS) in older patients with cancer is not yet clear. Indeed, randomized data on the effect of such interventions on survival and HRQoL are rare and conflicting. We describe the rationale and design of a phase III multicenter trial aimed at assessing the efficacy of geriatric intervention in the management of elderly patients with cancer. METHODS/

designApproximately 1200 patients, 70 years and older, considered in need of a geriatric intervention based on the G8 screening tool will be randomized into two intervention arms. The 'Usual-care' arm involves standard oncological care based on pre-defined oncological protocols. In addition to the standard oncological care, the 'Case-management' arm involves a multidimensional geriatric assessment and interventions tailored for the patient. Efficacy will be assessed using a co-primary endpoint encompassing OS and HRQoL. DISCUSSION: This trial has been designed to assess whether focused geriatric case management can either improve OS or HRQoL in elderly cancer patients considered in need of geriatric assessment.

trial registrationClinicaltrials.gov ID: NCT02704832 .

Indexed as

Clinical ProtocolsAgedAged, 80 and overAge FactorsHumansNeoplasmsResearch DesignAgedCancerCase-managementChemotherapyClinical trialElderlyGeriatric intervention

Identifiers

PMID27908282
PMCPMC5134290

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.