ArticleMedical physics2016
A preclinical microbeam facility with a conventional x-ray tube.
Article in Medical physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- A preclinical setup for spatially fractionated radiation therapy with electrons.Medical physics · 2026Article
- Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy.Pharmaceutics · 2022Review
- Quantification of Differential Response of Tumour and Normal Cells to Microbeam Radiation in the Absence of FLASH Effects.Cancers · 2021Article
- Clinical microbeam radiation therapy with a compact source: specifications of the line-focus X-ray tube.Physics and imaging in radiation oncology · 2020Article
- Evaluation of a pixelated large format CMOS sensor for x-ray microbeam radiotherapy.Medical physics · 2020Article
- Transfer of Minibeam Radiation Therapy into a cost-effective equipment for radiobiological studies: a proof of concept.Scientific reports · 2017Article
- Line focus x-ray tubes-a new concept to produce high brilliance x-rays.Physics in medicine and biology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeMicrobeam radiation therapy is an innovative treatment approach in radiation therapy that uses arrays of a few tens of micrometer wide and a few hundreds of micrometer spaced planar x-ray beams as treatment fields. In preclinical studies these fields efficiently eradicated tumors while normal tissue could effectively be spared. However, development and clinical application of microbeam radiation therapy is impeded by a lack of suitable small scale sources. Until now, only large synchrotrons provide appropriate beam properties for the production of microbeams.
methodsIn this work, a conventional x-ray tube with a small focal spot and a specially designed collimator are used to produce microbeams for preclinical research. The applicability of the developed source is demonstrated in a pilot in vitro experiment. The properties of the produced radiation field are characterized by radiochromic film dosimetry.
results50 μm wide and 400 μm spaced microbeams were produced in a 20 × 20 mm
conclusionsAt its current stage, the source is restricted to in vitro applications. However, moderate modifications of the setup may soon allow in vivo research in mice and rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.