ArticleAmerican journal of nephrology2017
The Impact of Health Care Appointment Non-Adherence on Graft Outcomes in Kidney Transplantation.
Article in American journal of nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05715580 (A Clinical Trial to Assess the Impact of Nursing Intervention in the Adherence to Drug Treatment and to a Healthy Lifestyle in Kidney Transplant Patients), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Clinical Trial to Assess the Impact of Nursing Intervention in the Adherence to Drug Treatment and to a Healthy Lifestyle in Kidney Transplant Patients
Who cites it
36 citing papers in PubMed.
- Associated Factors to Nonadherence to Routine Appointments after Kidney Transplantation: The ADHERE Brazil Study.Clinical transplantation · 2025Trial
- Article
- Factors Associated with Immunosuppressive Adherence in Liver Transplant Recipients Treated with Once- and Twice-Daily Tacrolimus.Medicina (Kaunas, Lithuania) · 2026Article
- Torque Teno Virus in Kidney Transplant Recipients: Perspectives on Its Role as a Complementary Marker in Monitoring Net Immunosuppression.Journal of clinical medicine · 2026Review
- Assessing Risk Factors and Posttransplant Outcomes of Nonadherence Among Kidney Transplant Recipients.Transplantation direct · 2025Article
- Predictors of Treatment Adherence in Kidney Transplant Patients: A Systematic Review of the Literature.Journal of clinical medicine · 2025Review
- Lived experiences for individuals with cystic fibrosis who have undergone lung transplantation: a qualitative study.BMC nursing · 2025Article
- Population pharmacokinetic modeling of missed mycophenolate mofetil doses: Impact on exposure and exploration of mitigation strategies.PloS one · 2025Article
- Variations in de novo donor-specific antibody development among HLA-DQ mismatches in kidney transplant recipients.PloS one · 2025Article
- Predictors of self-care in kidney transplant patients according to preoperative dialysis: A comparative study.Heliyon · 2024Article
- Transition of care from pediatric to adult nephrology post-renal transplant: a review.Translational pediatrics · 2024Review
- Challenges to establishing and maintaining kidney transplantation programs in developing countries: What are the coping strategies?World journal of methodology · 2024Review
- Medication non-adherence and its associated factors among kidney transplant patients in a large teaching hospital in Ethiopia.BMC nephrology · 2024Article
- Electronic health record-enabled routine assessment of medication adherence after solid organ transplantation: the time is now.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- A patient-centered interactive voice response system for supporting self-management in kidney transplantation: design and field testing.Frontiers in digital health · 2024Article
- Health-Promoting Lifestyle and Its Predictors in Renal Transplant Recipients in Hunan, China: A Cross-Sectional Study.Patient preference and adherence · 2024Article
- Associations between Missed Colonoscopy Appointments and Multiple Prior Adherence Behaviors in an Integrated Healthcare System: An Observational Study.Journal of general internal medicine · 2024Observational
- Language barriers and kidney transplantation in children.Pediatric nephrology (Berlin, Germany) · 2023Article
- Measurement of the Immunosuppressant Possession Ratio by Transplant Clinical Pharmacists Captures a Non-Adherence Associated With Antibody-Mediated Rejection.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- The combinatorial effect of age and biological sex on alloimmunity and transplantation outcome.Frontiers in transplantation · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundNon-adherence to medication is a well-studied and known cause of late allograft loss, but it is difficult to measure and prospectively monitor. The aim of this study was to assess if appointment non-adherence was correlated with medication non-adherence and a predictor of graft outcomes.
methodsThis was a longitudinal cohort study that used the National United States Renal Data System and veterans affairs health records data with time-to-event analyses conducted to assess the impact on graft and patient survival.
resultsThe number of transplants that were included in the analysis was 4,646 (3,656 with complete records); 14.6% of patients had an appointment no show rate of ≥12% (non-adherence). Appointment and medication non-adherence were highly correlated and both were significant independent predictors of outcomes. Those with appointment non-adherence had 1.5 times the risk of acute rejection (22.0 vs. 14.7%, p < 0.0001) and a 65% higher risk of graft loss (adjusted hazards ratio (aHR) 1.65, 95% CI 1.38-1.97, p < 0.0001). There was a significant interaction between appointment and medication non-adherence; those with appointment and medication non-adherence were at very high risk of graft loss (aHR 4.18, 95% CI 3.39-5.15, p < 0.0001), compared to those with only appointment non-adherence (aHR 1.39, 95% CI 0.97-2.01, p = 0.0766) or only medication non-adherence (aHR 2.44, 95% CI 2.11-2.81, p < 0.0001).
conclusionThese results demonstrate that non-adherence to health care appointments is a significant and independent risk factor for graft loss.
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