Evidence map›Paper›PMID 27907848›Full record

ArticleThe International journal on drug policy2017

Fatal and non-fatal overdose after narcology hospital discharge among Russians living with HIV/AIDS who inject drugs.

Alexander Y Walley, Debbie M Cheng, Emily K Quinn, Elena Blokhina, Natalia Gnatienko, Christine E Chaisson, Evgeny Krupitsky, Philip O Coffin, Jeffrey H Samet

Abstract read
In one paragraph

Article in The International journal on drug policy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alexander Y WalleyDepartment of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education Unit, Boston University School of Medicine & Boston Medical Center, 801 Massachusetts Avenue, Boston, USA. Electronic address: awalley@bu.edu.
Debbie M ChengDepartment of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, USA.
Emily K QuinnData Coordinating Center, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, USA.
Elena BlokhinaFirst Pavlov State Medical University, St. Petersburg, Russian Federation.
Natalia GnatienkoDepartment of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education Unit, Boston University School of Medicine & Boston Medical Center, 801 Massachusetts Avenue, Boston, USA.
Christine E ChaissonDepartment of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, USA; Data Coordinating Center, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, USA.
Evgeny KrupitskyFirst Pavlov State Medical University, St. Petersburg, Russian Federation; Bekhterev Research Psychoneurological Institute, St.Petersburg, Russian Federation.
Philip O CoffinSan Francisco Department of Public Health, San Francisco, CA 94102, USA; Division of HIV/AIDS, University of California San Francisco, San Francisco CA 94103, USA.
Jeffrey H SametDepartment of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education Unit, Boston University School of Medicine & Boston Medical Center, 801 Massachusetts Avenue, Boston, USA; Department of Community Health Sciences, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA, USA.
Boston University · USFirst Pavlov State Medical University of St. Petersburg · RUUniversity of California, San Francisco · US

Funding

URBAN ARCH (1/5) Administrative Coordinating Core (Admin Core)U24AA020778 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2011 to 2020
$3.5M
Linking Russian Narcology & HIV Care to Enhance Treatment, Retention, & OutcomesR01DA032082 · NIDA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2011 to 2015
$3.4M
NIAAA NIH HHS U24 AA020778NIDA NIH HHS R01 DA032082
6 · The paper itself

Abstract

objectivesAmong Russians living with HIV/AIDS who inject drugs, we examined the incidence of fatal and non-fatal overdoses following discharge from a narcology hospital and the associations with more advanced HIV infection.

designProspective cohort study of data collected at baseline, 3 and 6 months from HIV-infected patients with a history of injection drug use who were not treated with anti-retroviral therapy. Participants were recruited between 2012-2014 from a narcology (addiction) hospital in St. Petersburg, Russia.

methodsFatal overdose was determined based on contact reports to study staff in the year after discharge. Non-fatal overdose was self-reported at the 3- and 6-month assessments. The main independent variable for HIV severity was CD4 cell count at the baseline interview (<200cells/mm

resultsAmong 349 narcology patients, 18 participants died from overdose within one year after discharge (8.7%, 95% CI 3.4-14.2 by Kaplan-Meier); an estimated 51% [95% CI 34-68%] reported at least one non-fatal overdose within 6 months of discharge. HIV severity, time since HIV diagnosis and ever ART were not significantly associated with either fatal or non-fatal overdose events.

conclusionFatal and non-fatal overdose are common among Russians living with HIV/AIDS who inject drugs after narcology hospital discharge. Overdose prevention interventions are urgently warranted among Russian narcology patients with HIV infection.

Indexed as

AdolescentAdultAgedDrug OverdoseFemaleHIV InfectionsHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedProspective StudiesRisk FactorsRussiaSubstance Abuse, IntravenousSubstance Abuse Treatment CentersHIVInjection drug useMortalityOverdoseRussia

Identifiers

PMID27907848
PMCPMC5191979
OpenAlexW2559397878

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.