ArticlePloS one2016
Optimized Jasmonic Acid Production by Lasiodiplodia theobromae Reveals Formation of Valuable Plant Secondary Metabolites.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Mechanisms and Impact of Rhizosphere Microbial Metabolites on Crop Health, Traits, Functional Components: A Comprehensive Review.Molecules (Basel, Switzerland) · 2024Review
- Identification of Secondary Metabolites from the Mangrove-EndophyteMetabolites · 2023Article
- Genome Sequencing and Analysis Reveal Potential High-Valued Metabolites Synthesized byJournal of fungi (Basel, Switzerland) · 2023Article
- Optimizing the Culture Medium of Lasiodiplodia sp. to Improve the Yield of Ethyl Acetate Extract as an Antimicrobial Source.Current microbiology · 2022Article
- Indole-3-Carboxylic Acid From the Endophytic FungusFrontiers in cellular and infection microbiology · 2022Article
- Medicinal potentialities and pathogenic profile of Lasiodiplodia genus.World journal of microbiology & biotechnology · 2021Review
- Weed-Associated Fungal Endophytes as Biocontrol Agents ofJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Secondary Metabolites ofToxins · 2020Review
- Water Extract ofInternational journal of molecular sciences · 2019Article
- The fungal phytotoxin lasiojasmonate A activates the plant jasmonic acid pathway.Journal of experimental botany · 2018Article
- An allene oxide and 12-oxophytodienoic acid are key intermediates in jasmonic acid biosynthesis byJournal of lipid research · 2017Article
- A fungal catalase reacts selectively with the 13S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13S-hydroperoxide-dependent peroxidase activity.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Jasmonic acid is a plant hormone that can be produced by the fungus Lasiodiplodia theobromae via submerged fermentation. From a biotechnological perspective jasmonic acid is a valuable feedstock as its derivatives serve as important ingredients in different cosmetic products and in the future it may be used for pharmaceutical applications. The objective of this work was to improve the production of jasmonic acid by L. theobromae strain 2334. We observed that jasmonic acid formation is dependent on the culture volume. Moreover, cultures grown in medium containing potassium nitrate as nitrogen source produced higher amounts of jasmonic acid than analogous cultures supplemented with ammonium nitrate. When cultivated under optimal conditions for jasmonic acid production, L. theobromae secreted several secondary metabolites known from plants into the medium. Among those we found 3-oxo-2-(pent-2-enyl)-cyclopentane-1-butanoic acid (OPC-4) and hydroxy-jasmonic acid derivatives, respectively, suggesting that fungal jasmonate metabolism may involve similar reaction steps as that of plants. To characterize fungal growth and jasmonic acid-formation, we established a mathematical model describing both processes. This model may form the basis of industrial upscaling attempts. Importantly, it showed that jasmonic acid-formation is not associated to fungal growth. Therefore, this finding suggests that jasmonic acid, despite its enormous amount being produced upon fungal development, serves merely as secondary metabolite.
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