ArticlePloS one2016
Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Pooled it
- The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis.Bioscience reports · 2018Pooled it
- Prognosis and factors related to anti-VEGF therapy in patients with retinal vein occlusion and concomitant carotid artery disease.Scientific reports · 2024Article
- Understanding the Etiopathogenesis of Non-Arteritic Anterior Ischemic Optic Neuropathy with Laboratory Findings.Beyoglu eye journal · 2024Article
- Platelet count and indices as postpartum hemorrhage risk factors: a retrospective cohort study.Journal of thrombosis and haemostasis : JTH · 2021Article
- Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma.Histology and histopathology · 2019Review
- Association between Platelet Parameters and Glaucoma Severity in Primary Open-Angle Glaucoma.Journal of ophthalmology · 2019Article
- The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review.International journal of ophthalmology · 2019Article
- The relationship between mean platelet volume and diabetic retinopathy: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2019Review
- Association between coagulation function and patients with primary angle closure glaucoma: a 5-year retrospective case-control study.BMJ open · 2017Article
- The correlation of routine hematological indices with pterygium.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRetinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG.
methodsA total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48). A complete ophthalmological examination including visual field examination, A-scan ultrasound, Fundus photography, and measurement of platelet parameters were performed for NVG subjects.
resultsThere was no statistical difference in the mean age and gender among the RVO, DR, and control groups (p>0.05). The mean level of platelet distribution width (PDW) was higher (p<0.001) in the RVO group (15.16±2.13fl) and DR group (16.17±1.66fl) when compared with the control group (13.77±2.99fl). The mean plateletcrit (PCT) value of the RVO group (0.229±0.063%) was also higher (p = 0.049) than the control group (0.199±0.045). In the DR group, mean platelet volume (MPV) value (10.72±1.57fl) was significantly higher (p = 0.002) than the control group (9.75±0.89fl). A similar trend was observed when platelet parameters were compared among the 3 groups with respect to age. The mean level of PDW was significantly higher (p<0.001) in the DR group (16.17±1.66fl) compared with the DM group (13.80±3.32fl). Stepwise multiple logistic regression analysis revealed that PDW (OR = 1.44, 95%CI = 1.149-1.805, p = 0.002) and MPV (OR = 1.503, 95%CI = 1.031-2.192, p = 0.034) were associated with the DR group, PDW (OR = 1.207, 95%CI = 1.010-1.443, p = 0.039) and PCT (OR = 1.663, 95%CI = 1.870-2.654, p = 0.036) were associated with the RVO group.
conclusionOur results suggest that increased PDW and MPV are associated with the NVG secondary to DR group, elevated PDW and PCT are associated with the RVO group. It indicates that platelets might be an important factor in the onset and/or development of NVG.
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