Evidence map›Paper›PMID 27906866›Full record

ReviewCurrent opinion in pediatrics2017

Inherited and acquired disorders of magnesium homeostasis.

Matthias Tilmann Florian Wolf

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Current opinion in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Fluorescence Properties and MgChemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. MgAmerican journal of physiology. Renal physiology · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Matthias Tilmann Florian WolfDivision of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
The University of Texas Southwestern Medical Center · US

Funding

The Role of Uromodulin in the Regulation of the Renal Calcium Channel TRPV5K08DK095994 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WOLF, MATTHIAS TILMANN FLORIAN · 2012 to 2015
$581k
Renal Regulation of the Magnesium Channel TRPM6 by UromodulinR03DK111776 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WOLF, MATTHIAS TILMANN FLORIAN · 2017 to 2018
$162k
NIDDK NIH HHS K08 DK095994NIDDK NIH HHS R03 DK111776
6 · The paper itself

Abstract

purpose of reviewMagnesium (Mg) imbalances are frequently overlooked. Hypermagnesemia usually occurs in preeclamptic women after Mg therapy or in end-stage renal disease patients, whereas hypomagnesemia is more common with a prevalence of up to 15% in the general population. Increasing evidence points toward a role for mild-to-moderate chronic hypomagnesemia in the pathogenesis of hypertension, type 2 diabetes mellitus, and metabolic syndrome. RECENT

findingsThe kidneys are the major regulator of total body Mg homeostasis. Over the last decade, the identification of the responsible genes in rare genetic disorders has enhanced our understanding of how the kidney handles Mg. The different genetic disorders and medications contributing to abnormal Mg homeostasis are reviewed. SUMMARY: As dysfunctional Mg homeostasis contributes to the development of many common human disorders, serum Mg deserves closer monitoring. Hypomagnesemic patients may be asymptomatic or may have mild symptoms. In severe hypomagnesemia, patients may present with neurological symptoms such as seizures, spasms, or cramps. Renal symptoms include nephrocalcinosis and impaired renal function. Most conditions affect tubular Mg reabsorption by disturbing the lumen-positive potential in the thick ascending limb or the negative membrane potential in the distal convoluted tubule.

Indexed as

Diagnosis, DifferentialFemaleGenetic Predisposition to DiseaseHepatocyte Nuclear Factor 1-betaHomeostasisHumansHypercalciuriaKidneyMagnesiumMagnesium DeficiencyMaleNephrocalcinosisPrognosisRenal Tubular Transport, Inborn ErrorsRisk AssessmentHepatocyte Nuclear Factor 1-betaHNF1B protein, humanMagnesium

Identifiers

PMID27906866
PMCPMC5572672
OpenAlexW2557726613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.