Evidence map›Paper›PMID 27906670›Full record

ArticleOncotarget2017

Stag3 regulates microtubule stability to maintain euploidy during mouse oocyte meiotic maturation.

Mianqun Zhang, Xiaoxin Dai, Yalu Sun, Yajuan Lu, Changyin Zhou, Yilong Miao, Ying Wang, Bo Xiong

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Kinesin motor KIF16A regulates microtubule stability and actin-dependent spindle migration in mouse oocyte meiosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Chromosome Segregation in the Oocyte: What Goes Wrong during Aging.International journal of molecular sciences · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Postovulatory aging causes the deterioration of porcine oocytes via induction of oxidative stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mianqun ZhangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Xiaoxin DaiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Yalu SunCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Yajuan LuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Changyin ZhouCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Yilong MiaoCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Ying WangDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
Bo XiongCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Nanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stag3, a meiosis-specific subunit of cohesin complex, has been demonstrated to function in both male and female reproductive systems in mammals. However, its roles during oocyte meiotic maturation have not been fully defined. In the present study, we report that Stag3 uniquely accumulates on the spindle apparatus and colocalizes with microtubule fibers during mouse oocyte meiotic maturation. Depletion of Stag3 by gene-targeting morpholino disrupts normal spindle assembly and chromosome alignment in oocytes. We also find that depletion of Stag3 reduces the acetylated level of tubulin and microtubule resistance to microtubule depolymerizing drug, suggesting that Stag3 is required for microtubule stability. Consistent with these observations, kinetochore-microtubule attachment, an important mechanism controlling chromosome alignment, is severely impaired in Stag3-depleted oocytes, resultantly causing the significantly increased incidence of aneuploid eggs. Collectively, our data reveal that Stag3 is a novel regulator of microtubule dynamics to ensure euploidy during moue oocyte meiotic maturation.

Indexed as

AneuploidyAnimalsCell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosome SegregationCohesinsFemaleGene Knockdown TechniquesKinetochoresMeiosisMiceMice, Inbred ICRMicrotubulesMorpholinosM Phase Cell Cycle CheckpointsNuclear ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsMorpholinosNuclear ProteinsStag3 protein, mouseTubulinTubulin Modulatorsaneuploid eggchromosome alignmentmicrotubule stabilityspindle assemblyStag3

Identifiers

PMID27906670
PMCPMC5352080
OpenAlexW2558754824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.