SynthesisTherapeutic hypothermia and temperature management2016
Time to Cooling Is Associated with Resuscitation Outcomes.
Synthesis in Therapeutic hypothermia and temperature management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04955288 (Research on Key Technologies and System Optimization of Early Warning and Resuscitation of Cardiac Arrest), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Research on Key Technologies and System Optimization of Early Warning and Resuscitation of Cardiac Arrest
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- ECPR combined with CRRT successfully rescues a patient who experienced sudden cardiac arrest for 152 minutes: A case report.Medicine · 2025Article
- Variability in temperature control practices amongst the Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial.Resuscitation · 2024Article
- Assessing variations in care delivered to rural out of hospital cardiac arrest patients in the interfacility transfer setting.Journal of the American College of Emergency Physicians open · 2024Article
- Therapeutic hypothermia is not dead, but hibernating!Clinical and experimental emergency medicine · 2024Article
- Article
- Re: "Therapeutic Hypothermia for Hypoxic-Ischemic Brain Injury Is More Effective in Newborn Infants Than in Older Patients: Review and Hypotheses" by Whitelaw and Thoresen.Therapeutic hypothermia and temperature management · 2024Article
- The Identification of Subsequent Events Following Out-of-Hospital Cardiac Arrests with Targeted Temperature Management.Acta Cardiologica Sinica · 2023Article
- A Commentary on the Effect of Targeted Temperature Management in Patients Resuscitated from Cardiac Arrest.Therapeutic hypothermia and temperature management · 2023Article
- Optimal Timing of Targeted Temperature Management for Post-Cardiac Arrest Syndrome: Is Sooner Better?Journal of clinical medicine · 2023Article
- Article
- Targeted temperature management evolving over time-A local process analysis.Acta anaesthesiologica Scandinavica · 2022Article
- Extracorporeal cardiopulmonary resuscitation with temperature management could improve the neurological outcomes of out-of-hospital cardiac arrest: a retrospective analysis of a nationwide multicenter observational study in Japan.Journal of intensive care · 2022Article
- Article
- Outcomes of patients with refractory out-of-hospital cardiac arrest transported to an ECMO centre compared with transport to non-ECMO centres.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Mild therapeutic hypothermia after out-of-hospital cardiac arrest: What does really matter?Cardiology journal · 2021Observational
- Ultrafast Hypothermia Selectively Mitigates the Early Humoral Response After Cardiac Arrest.Journal of the American Heart Association · 2020Article
- Precision and Safety of an Intravascular Temperature Management System for Postcardiac Arrest Syndrome Patients: A Multicenter Clinical Trial (COOL-ARREST JP).Therapeutic hypothermia and temperature management · 2020Article
- Neurologic prognostication after resuscitation from cardiac arrest.Journal of the American College of Emergency Physicians open · 2020Review
- State-of-the-art considerations in post-arrest care.Journal of the American College of Emergency Physicians open · 2020Review
- Therapeutic hypothermia promotes cerebral blood flow recovery and brain homeostasis after resuscitation from cardiac arrest in a rat model.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our purpose was to analyze evidence related to timing of cooling from studies of targeted temperature management (TTM) after return of spontaneous circulation (ROSC) after cardiac arrest and to recommend directions for future therapy optimization. We conducted a preliminary review of studies of both animals and patients treated with post-ROSC TTM and hypothesized that a more rapid cooling strategy in the absence of volume-adding cold infusions would provide improved outcomes in comparison with slower cooling. We defined rapid cooling as the achievement of 34°C within 3.5 hours of ROSC without the use of volume-adding cold infusions, with a ≥3.0°C/hour rate of cooling. Using the PubMed database and a previously published systematic review, we identified clinical studies published from 2002 through 2014 related to TTM. Analysis included studies with time from collapse to ROSC of 20-30 minutes, reporting of time from ROSC to target temperature and rate of patients in ventricular tachycardia or ventricular fibrillation, and hypothermia maintained for 20-24 hours. The use of cardiopulmonary bypass as a cooling method was an exclusion criterion for this analysis. We compared all rapid cooling studies with all slower cooling studies of ≥100 patients. Eleven studies were initially identified for analysis, comprising 4091 patients. Two additional studies totaling 609 patients were added based on availability of unpublished data, bringing the total to 13 studies of 4700 patients. Outcomes for patients, dichotomized into faster and slower cooling approaches, were determined using weighted linear regression using IBM SPSS Statistics software. Rapid cooling without volume-adding cold infusions yielded a higher rate of good neurological recovery than slower cooling methods. Attainment of a temperature below 34°C within 3.5 hours of ROSC and using a cooling rate of more than 3°C/hour appear to be beneficial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.