Evidence map›Paper›PMID 27906197›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2017

Treatment and follow-up of venous thrombosis in the neonatal intensive care unit: a retrospective study.

J C Bohnhoff, S A DiSilvio, R K Aneja, J R Shenk, Y A Domnina, B S Brozanski, M Good

Open access · greenAbstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A Critical Evaluation of Enoxaparin Dose Adjustment Guidelines in Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

J C BohnhoffUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
S A DiSilvioDivision of Newborn Medicine, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
R K AnejaUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
J R ShenkDepartment of Pharmacy, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Y A DomninaUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
B S BrozanskiUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
M GoodUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Children's Hospital of Pittsburgh · USUniversity of Pittsburgh · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1R01GM098474 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANEJA, RAJESH K. · 2012 to 2016
$1.4M
Novel Anti-Inflammatory Properties of Breast Milk in Necrotizing EnterocolitisK08DK101608 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2014 to 2017
$584k
NCATS NIH HHS UL1 TR001857NIDDK NIH HHS K08 DK101608NIGMS NIH HHS R01 GM098474
6 · The paper itself

Abstract

objectiveThe critically ill, premature patients of neonatal intensive care units are susceptible to venous thrombosis, an adverse event associated with short- and long-term morbidity. Venous thrombosis is frequently treated with low-molecular-weight heparins (LMWHs) such as enoxaparin, but optimal dosing of LMWH must balance the morbidity of venous thrombosis with the potential adverse affects of anticoagulation. The optimal dosing of enoxaparin for premature infants is unclear. The objective of this study was to describe enoxaparin therapy and follow-up in critically ill neonates diagnosed with venous thrombosis. STUDY

designRetrospective medical record review in the neonatal intensive care unit (NICU) in a single tertiary care institution. Infants with venous thrombosis diagnosed in the NICU were identified using preexisting quality improvement lists and medical records.

resultsTwenty-six infants with 30 venous thromboses were identified with a median gestational age of 31 weeks at birth. Eighteen (69%) infants received enoxaparin for venous thrombosis during their hospitalization, beginning with a median dose of 1.5 mg kg

conclusionOur data reinforce the relative safety and necessity of enoxaparin doses above 1.5 mg kg

Indexed as

Infant, PrematureAnticoagulantsEnoxaparinFemaleFollow-Up StudiesHospitalizationHumansInfantInfant, NewbornIntensive Care Units, NeonatalMalePennsylvaniaRetrospective StudiesTertiary Care CentersVenous ThrombosisAnticoagulantsEnoxaparin

Identifiers

PMID27906197
PMCPMC5334277
OpenAlexW2558652967

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.