ArticleJournal of perinatology : official journal of the California Perinatal Association2017
Congenital hypothyroidism with delayed thyroid-stimulating hormone elevation in premature infants born at less than 30 weeks gestation.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04208503 (Ultrasound and Functional Thyroid Evaluation in Preterm Infants Born Between 24 and 32 Weeks of Gestation), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultrasound and Functional Thyroid Evaluation in Preterm Infants Born Between 24 and 32 Weeks of Gestation
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Thyroid Function in 509 Premature Newborns Below 31 Weeks of Gestational Age: Evaluation and Follow-upJournal of clinical research in pediatric endocrinology · 2022Article
- Article
- Abnormal thalamocortical connectivity of preterm infants with elevated thyroid stimulating hormone identified with diffusion tensor imaging.Scientific reports · 2022Article
- Thyroxine and Thyroid-Stimulating Hormone in Own Mother's Milk, Donor Milk, and Infant Formula.Life (Basel, Switzerland) · 2022Article
- Utility of Repeat Testing for Congenital Hypothyroidism in Infants with Very Low Birth Weight.The Journal of pediatrics · 2022Article
- Correlation Between Thyroid Hormone Concentrations and Ultrasound Thyroid Volume in Preterm Infants Born Before 33 Weeks of Gestation.Frontiers in endocrinology · 2022Observational
- Targeted Secondary Screening for Congenital Hypothyroidism in High-Risk Neonates: A 9 Year Review in a Large California Health Care System.International journal of neonatal screening · 2021Article
- Guideline for the Treatment of Hypothyroidism in Prematurity.International journal of preventive medicine · 2021Review
- Small for gestational age is a risk factor for thyroid dysfunction in preterm newborns.BMC pediatrics · 2020Article
- Pituitary Glycoprotein Hormones in Human Milk before and after Pasteurization or Refrigeration.Nutrients · 2020Article
- Dynamic Change of Thyroid Hormones With Postmenstrual Age in Very Preterm Infants Born With Gestational Age <32 Weeks: A Multicenter Prospective Cohort Study.Frontiers in endocrinology · 2020Article
- Review
- Thyroid dysfunction in preterm infants born before 32 gestational weeks.BMC pediatrics · 2019Article
- The value of serial newborn screening for congenital hypothyroidism using thyroxine (T4) in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Congenital Hypothyroidism in Preterm Newborns: A Retrospective Study Arising from a Screening Program in Fars Province, Southwestern Iran.Oman medical journal · 2019Article
- Article
- Antenatal steroids and thyroid hormone function in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Thyroid gland volumes in premature infants using serial ultrasounds.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- The complex aetiology of cerebral palsy.Nature reviews. Neurology · 2018Review
- Hypothyroidism in Infants With Congenital Heart Disease Exposed to Excess Iodine.Journal of the Endocrine Society · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCongenital hypothyroidism (CH) with delayed thyroid-stimulating hormone (TSH) elevation is a common form of thyroid dysfunction among premature infants. Routine newborn screening (NBS) may miss infants with CH with delayed TSH elevation. The objective of the study is to determine the prevalence of CH with delayed TSH elevation in premature infants and to identify associated risk factors. STUDY
designRetrospective analysis of serum thyroid function screening (TFS) at day of life 30 in premature infants <30 weeks gestation, admitted to University of Iowa Neonatal Intensive Care Unit between 1 July 2012 to 30 June 2015. Serum free thyroxine and TSH levels were obtained in premature infants <30 weeks gestation on day of life 30. Follow-up testing and pediatric endocrinology consultation were done according to the institutional protocol.
resultIn total, 286 infants were included. All infants underwent routine NBS and 280 patients underwent TFS. Twenty-six patients (9.1%) were diagnosed with thyroid dysfunction. NBS identified only three patients. CH with delayed TSH elevation was diagnosed in 20 patients (6.9%) and was significantly associated with multiple gestation, lower birth weight, higher gestational age and lower 5 min APGAR score.
conclusionThyroid dysfunction is common among premature infants born before 30 weeks gestation. The majority of cases with thyroid dysfunction had CH with delayed TSH elevation, which was not detected by NBS. We recommend measurement of serum TSH and free T4 levels on day of life 30 in premature infants born at <30 weeks gestation to identify patients with CH with delayed TSH elevation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.