ArticleItalian journal of pediatrics2016
Neonatal diffusion tensor brain imaging predicts later motor outcome in preterm neonates with white matter abnormalities.
Article in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
- The impact of small for gestational age on visual-motor integration in preterm infants: insights from early brain magnetic resonance imaging.Translational pediatrics · 2026Article
- Longitudinal White Matter Maturation in Preterm Infants: Functional Pathway-Specific Trajectories and Associations with Motor Outcomes.Journal of clinical medicine · 2026Article
- Association between movement impairments and glymphatic system dysfunction in spastic diplegic cerebral palsy using DTI-ALPS.Neuroradiology · 2025Article
- Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally.Scientific reports · 2023Article
- White matter microstructure predicts individual differences in infant fear (But not anger and sadness).Developmental science · 2023Article
- The relationship between interhemispheric synchrony, morphine and microstructural development of the corpus callosum in extremely preterm infants.Human brain mapping · 2022Article
- Neuroimaging of structural and functional connectivity in preterm infants with intraventricular hemorrhage.Seminars in perinatology · 2022Review
- Abnormal thalamocortical connectivity of preterm infants with elevated thyroid stimulating hormone identified with diffusion tensor imaging.Scientific reports · 2022Article
- Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies.Human brain mapping · 2022Article
- Magnetic Resonance Imaging Evaluation of Perinatal Hypoxic Ischemic Encephalopathy: An Institutional Experience.Journal of neurosciences in rural practice · 2022Article
- Effects of intraventricular hemorrhage on white matter microstructural changes at term and early developmental outcomes in infants born very preterm.Neuroradiology · 2021Article
- Brain White Matter Maturation and Early Developmental Outcomes in Preterm Infants With Retinopathy of Prematurity.Investigative ophthalmology & visual science · 2021Observational
- Delayed Maturation of the Middle Cerebellar Peduncles at Near-Term Age Predicts Abnormal Neurodevelopment in Preterm Infants.Neonatology · 2021Article
- Multiparametric Analysis of Cerebral Development in Preterm Infants Using Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Article
- Neonatal Functional and Structural Connectivity Are Associated with Cerebral Palsy at Two Years of Age.American journal of perinatology · 2020Article
- Cerebral White Matter Maturation Patterns in Preterm Infants: An MRI T2 Relaxation Anisotropy and Diffusion Tensor Imaging Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhite matter (WM) abnormalities associated with prematurity are one of the most important causes of neurological disability that involves spastic motor deficits in preterm newborns. This study aimed to evaluate regional microstructural changes in diffusion tensor imaging (DTI) associated with WM abnormalities.
methodsWe prospectively studied extremely low birth weight (ELBW; <1000 g) preterm infants who were admitted to the Neonatal Intensive Care Unit of Hanyang University Hospital between February 2011 and February 2014. WM abnormalities were assessed with conventional magnetic resonance (MR) imaging and DTI near term-equivalent age before discharge. Region-of-interests (ROIs) measurements were performed to examine the regional distribution of fractional anisotropy (FA) values.
resultsThirty-two out of 72 ELBW infants underwent conventional MR imaging and DTI at term-equivalent age. Ten of these infants developed WM abnormalities associated with prematurity. Five of ten of those with WM abnormalities developed cerebral palsy (CP). DTI in the WM abnormalities with CP showed a significant reduction of mean FA in the genu of the corpus callosum (p = 0.022), the ipsilateral posterior limb of the internal capsule (p = 0.019), and the ipsilateral centrum semiovale (p = 0.012) compared to normal WM and WM abnormalities without CP. In infants having WM abnormalities with CP, early FA values in neonatal DTI revealed abnormalities of the WM regions prior to the manifestation of hemiparesis.
conclusionsDTI performed at term equivalent age shows different FA values in WM regions among infants with or without WM abnormalities associated with prematurity and/or CP. Low FA values of ROIs in DTI are related with later development of spastic CP in preterm infants with WM abnormalities.
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