ArticleJournal of translational medicine2016
CDKN2B methylation is associated with carotid artery calcification in ischemic stroke patients.
Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.Pharmacology & therapeutics · 2019Pooled it
- Curcumin reduces neuroinflammation and oxidative stress in a stroke model by epigenetically regulating ADRB2 methylation through JAK2/STAT3 and Nrf2/HO-1 pathways.Journal of neuroinflammation · 2026Article
- Blood-Based Whole-Genome Methylation Analysis of Yili Horses Pre- and Post-Racing.Animals : an open access journal from MDPI · 2025Article
- Relationship Between Dietary Inflammatory Index and Carotid Artery Calcification in Patients with Ischemic Stroke.Journal of inflammation research · 2024Article
- Identification and validation of cortisol-related hub biomarkers and the related pathogenesis of biomarkers in Ischemic Stroke.Brain and behavior · 2024Article
- Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection.Clinical epigenetics · 2023Article
- Attenuation of Piwil2 induced by hypoxic postconditioning prevents cerebral ischemic injury by inhibiting CREB2 promoter methylation.Brain pathology (Zurich, Switzerland) · 2023Article
- Correlation BetweenClinical interventions in aging · 2023Article
- HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case-control study and a prospective nested case-control study.Clinical epigenetics · 2022Article
- Mendelian Randomization Analysis of the Association of SOCS3 Methylation with Abdominal Obesity.Nutrients · 2022Article
- Article
- Advancement of epigenetics in stroke.Frontiers in neuroscience · 2022Review
- Methylation of theNeuropsychiatric disease and treatment · 2021Article
- The values of AHCY and CBS promoter methylation on the diagnosis of cerebral infarction in Chinese Han population.BMC medical genomics · 2020Article
- Retracted Article: LncRNA OIP5-AS1 contributes to ox-LDL-induced inflammation and oxidative stress through regulating the miR-128-3p/CDKN2A axis in macrophages.RSC advances · 2019Article
- Methylation of the CDKN2A Gene Increases the Risk of Brain Arteriovenous Malformations.Journal of molecular neuroscience : MN · 2019Article
- Association between promoter DNA methylation and gene expression in the pathogenesis of ischemic stroke.Aging · 2019Article
- Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia.American journal of translational research · 2019Article
- Study of Promoter Methylation Patterns of HOXA2, HOXA5, and HOXA6 and Its Clinicopathological Characteristics in Colorectal Cancer.Frontiers in oncology · 2019Article
- Involvement of methylation-associated silencing of formin 2 in colorectal carcinogenesis.World journal of gastroenterology · 2018Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) near chromosome 9p21 have been associated with both atherosclerosis and artery calcification, but the underlying mechanisms remained largely unknown. Considering that CDKN2A/2B is a frequently reported site for DNA methylation, this study aimed to evaluate whether carotid artery calcification (CarAC) is related to methylation levels of CDKN2A/2B in patients with ischemic stroke.
methodsDNA methylation levels of CDKN2A/2B were measured in 322 ischemic stroke patients using peripheral blood leukocytes. Methylation levels of 36 CpG sites around promoter regions of CDKN2A/2B were examined with BiSulfite Amplicon Sequencing. CarAC was quantified with Agatston score based on results of computed tomography angiography. Generalized liner model was performed to explore the association between methylation levels and CarAC.
resultsOf the 322 analyzed patients, 187 (58.1%) were classified as with and 135 (41.9%) without evident CarAC. The average methylation levels of CDKN2B were higher in patents with CarAC than those without (5.7 vs 5.4, p = 0.001). After adjustment for potential confounders, methylation levels of CDKN2B were positively correlated with cube root transformed calcification scores (β = 0.591 ± 0.172, p = 0.001) in generalized liner model. A positive correlation was also detected between average methylation levels of CDKN2B and cube root transformed calcium volumes (β = 0.533 ± 0.160, p = 0.001).
conclusionsDNA methylation of CDKN2B may play a potential role in artery calcification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.