Evidence map›Paper›PMID 27905880›Full record

ArticleBMC bioinformatics2016

The Lair: a resource for exploratory analysis of published RNA-Seq data.

Harold Pimentel, Pascal Sturmfels, Nicolas Bray, Páll Melsted, Lior Pachter

Abstract read
In one paragraph

Article in BMC bioinformatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. TransAtlasDB: an integrated database connecting expression data, metadata and variants.Database : the journal of biological databases and curation · 2018
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Harold PimentelDepartment of Computer Science, University of California, Berkeley, 387 Soda Hall, Berkeley, 94720, USA.
Pascal SturmfelsDepartment of Computer Science, University of Michigan, 486 Vassar Avenue, Berkeley, CA, 94708, USA.
Nicolas BrayInnovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA, 94720, USA.
Páll MelstedFaculty of Industrial Engineering, Mechanical Engineering and Computer Science, University of Iceland, Dunhagi 5, 107, Reykjavík, Iceland.
Lior PachterDepartment of Computer Science, University of California, Berkeley, 387 Soda Hall, Berkeley, 94720, USA. lpachter@math.berkeley.edu.

Funding

Erythroid stage-specific transcriptome expression, dynamics, and regulationR01DK094699 · NIDDK · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CONBOY, JOHN G, PACHTER, LIOR S · 2011 to 2015
$2.3M
Algorithms and Software for Provably Accurate De Novo RNA-Seq AssemblyR01HG008164 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI KANNAN, SREERAM, PACHTER, LIOR S · 2015 to 2017
$1.4M
Methods for the analysis of RNA-Seq and related sequence census based experimentsR01HG006129 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI PACHTER, LIOR S · 2011 to 2013
$1.1M
NHGRI NIH HHS R01 HG006129NHGRI NIH HHS R01 HG008164NIDDK NIH HHS R01 DK094699
6 · The paper itself

Abstract

Increased emphasis on reproducibility of published research in the last few years has led to the large-scale archiving of sequencing data. While this data can, in theory, be used to reproduce results in papers, it is difficult to use in practice. We introduce a series of tools for processing and analyzing RNA-Seq data in the Sequence Read Archive, that together have allowed us to build an easily extendable resource for analysis of data underlying published papers. Our system makes the exploration of data easily accessible and usable without technical expertise. Our database and associated tools can be accessed at The Lair: http://pachterlab.github.io/lair .

Indexed as

Databases, Nucleic AcidSoftwareHigh-Throughput Nucleotide SequencingHumansReproducibility of ResultsSequence Analysis, RNAExploratory data analysisInteractive visualizationKallistoReanalysisReproducibilityRNA-SeqSequence read archiveShinySleuth

Identifiers

PMID27905880
PMCPMC5131447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.