ArticleBMC genomics2016
Comparative genomics of Beauveria bassiana: uncovering signatures of virulence against mosquitoes.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Genomic signatures of host-range divergence in the generalist Beauveria bassiana and the specialist Beauveria brongniartii.Molecular genetics and genomics : MGG · 2026Article
- Genome-wide exploration of biosynthetic gene clusters and their association with virulence in the entomopathogenic fungus Beauveria.Functional & integrative genomics · 2026Article
- Gene presence-absence and evolutionary signals of positive selection associated with virulence divergence inMicrobial genomics · 2026Article
- Effects of Insect Cuticular Compounds on Appressorium Formation and Metabolic Activity inJournal of fungi (Basel, Switzerland) · 2025Article
- A binary-distributed effector modulates fungal host preference for drosophilids by targeting a lineage-specific immune factor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Larvicidal and Immunomodulatory Effects of Conidia and Blastospores ofJournal of fungi (Basel, Switzerland) · 2025Article
- Transcriptomic Analysis Reveals Molecular Mechanisms Underpinning Mycovirus-Mediated Hypervirulence inJournal of fungi (Basel, Switzerland) · 2025Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus.BMC biology · 2024Article
- Computational identification and characterization of chitinase 1 and chitinase 2 from neotropical isolates ofFrontiers in bioinformatics · 2024Article
- A bacterial-like Pictet-Spenglerase drives the evolution of fungi to produce β-carboline glycosides together with separate genes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genomic virulence features of Beauveria bassiana as a biocontrol agent for the mountain pine beetle population.BMC genomics · 2023Article
- Genomic Characterization and Functional Description ofJournal of fungi (Basel, Switzerland) · 2023Article
- The Sordariomycetes: an expanding resource with Big Data for mining in evolutionary genomics and transcriptomics.Frontiers in fungal biology · 2023Review
- Male-killer symbiont screening reveals novel associations inAccess microbiology · 2023Article
- Draft Genome Sequences of Eight Isolates of Beauveria bassiana of Neotropical Origin.Microbiology resource announcements · 2022Article
- The Entomopathogenic FungusJournal of fungi (Basel, Switzerland) · 2022Review
- Genomic and Experimental Analysis of the Insecticidal Factors Secreted by the Entomopathogenic FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Comparative mitogenome analysis reveals mitochondrial genome characteristics in eight strains ofPeerJ · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEntomopathogenic fungi such as Beauveria bassiana are promising biological agents for control of malaria mosquitoes. Indeed, infection with B. bassiana reduces the lifespan of mosquitoes in the laboratory and in the field. Natural isolates of B. bassiana show up to 10-fold differences in virulence between the most and the least virulent isolate. In this study, we sequenced the genomes of five isolates representing the extremes of low/high virulence and three RNA libraries, and applied a genome comparison approach to uncover genetic mechanisms underpinning virulence.
resultsA high-quality, near-complete genome assembly was achieved for the highly virulent isolate Bb8028, which was compared to the assemblies of the four other isolates. Whole genome analysis showed a high level of genetic diversity between the five isolates (2.85-16.8 SNPs/kb), which grouped into two distinct phylogenetic clusters. Mating type gene analysis revealed the presence of either the MAT1-1-1 or the MAT1-2-1 gene. Moreover, a putative new MAT gene (MAT1-2-8) was detected in the MAT1-2 locus. Comparative genome analysis revealed that Bb8028 contains 163 genes exclusive for this isolate. These unique genes have a tendency to cluster in the genome and to be often located near the telomeres. Among the genes unique to Bb8028 are a Non-Ribosomal Peptide Synthetase (NRPS) secondary metabolite gene cluster, a polyketide synthase (PKS) gene, and five genes with homology to bacterial toxins. A survey of candidate virulence genes for B. bassiana is presented.
conclusionsOur results indicate several genes and molecular processes that may underpin virulence towards mosquitoes. Thus, the genome sequences of five isolates of B. bassiana provide a better understanding of the natural variation in virulence and will offer a major resource for future research on this important biological control agent.
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