Evidence map›Paper›PMID 27905835›Full record

Observational studyHuman vaccines & immunotherapeutics2017

Hemagglutination inhibiting antibody persistence 1 year after influenza vaccination in Korean children and adolescents.

Eun Kyeong Kang, Byung Wook Eun, Nam Hee Kim, Yun Kyung Kim, Jung Sub Lim, Dong Ho Kim

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Eun Kyeong Kanga Department of Pediatrics , Dongguk University Ilsan Hospital , Goyang , South Korea.
Byung Wook Eunb Department of Pediatrics , Eulji General Hospitl , Seoul , South Korea.
Nam Hee Kimc Department of Pediatrics , Inje University Ilsan Paik Hospital , Goyang , South Korea.
Yun Kyung Kimd Department of Pediatrics , Korea University Ansan Hospital , Ansan , South Korea.
Jung Sub Lime Department of Pediatrics , Korea Cancer Center Hospital , Seoul , South Korea.
Dong Ho Kime Department of Pediatrics , Korea Cancer Center Hospital , Seoul , South Korea.
Dongguk University Ilsan Hospital · KREulji Medical Center · KRInje University Ilsan Paik Hospital · KRKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to assess the 1-y immunogenicity of influenza vaccines and the association between immunogenicity at 1 m and further influenza infections in children aged 6 m to 18 y. Serum hemagglutination inhibition (HI) antibody titers and GMTs were determined for the recommended influenza strains 0, 1, 6, and 12 m post-vaccination. The serological evidence of influenza infections were defined as the increase of HI titer (HI ≥1:40 and 4-fold rise). The seroprotection rates for strains A(H1N1), A(H3N2), and B were 91.2%, 87.6%, and 87.6%, respectively, at 1 month (n = 174). These rates were 76.5%, 64.7%, and 54.6%, respectively, at 12 m. The seroprotection rates and GMTs for influenza A(H1N1) and A(H3N2) were higher at 12 m than at 0 m (p < 0.05) but not for B. There were 39 subjects (42 cases) of serological influenza infections. Subjects with seroprotection at 1 m post-vaccination had showed fewer serologic A(H1N1) (10.1 vs 54.5%) and A(H3N2) (7.2 vs 38.1%) infections than the ones with HI titer <1:40 during follow-up (P < 0.01). In conclusion, influenza vaccines used during the 2008-09 season induced adequate 1-y immunogenicity for A(H1N1) and A(H3N2). The immunogenicity at one month after vaccination influenced further serological influenza infections.

Indexed as

Hemagglutination Inhibition TestsAdolescentAntibodies, ViralChildChild, PreschoolFemaleHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza B virusInfluenza VaccinesMaleRepublic of KoreaTime FactorsAntibodies, ViralInfluenza Vaccines1-year immunogenicitychildrenhemagglutination inhibitioninfluenza vaccineseroprotection rate

Identifiers

PMID27905835
PMCPMC5404370
OpenAlexW2559199741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.