Evidence map›Paper›PMID 27905821›Full record

ArticleHuman vaccines & immunotherapeutics2017

Effects of hepatitis B vaccine boosters on anti-HBs-negative children after primary immunization.

Shunshun Lu, Jingjing Ren, Qian Li, Zhenggang Jiang, Yongdi Chen, Kaijin Xu, Bing Ruan, Shigui Yang, Tiansheng Xie, Linna Yang and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Shunshun Lua School of Medicine, Ningbo University , Ningbo , China.
Jingjing Renb State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
Qian Lic Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Zhenggang Jiangc Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Yongdi Chenc Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Kaijin Xub State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
Bing Ruanb State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
Shigui Yangb State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
Tiansheng Xieb State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
Linna Yanga School of Medicine, Ningbo University , Ningbo , China.
Jing Lid Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
Jun Yaoc Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Zhejiang Center for Disease Control and Prevention · CNState Key Laboratory of Diagnosis and Treatment of Infectious DiseasesNingbo University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was aimed at evaluating the changes of hepatitis B surface antibody (anti-HBs) titer after booster vaccinations in 5-15-year-old children with negative antibodies (<10 mIU/mL). 225 subjects (mean age, 9.28 ± 2.95 years) included in the study consisted of 123 males and 102 females, with a complete hepatitis B vaccination during infancy. The participants were divided into 3 groups according to their pre-booster anti-HBs level: Group I, <0.1 mIU/mL; Group II, 0.1 to <1.0 mIU/mL; Group III, 1.0 to <10.0 mIU/mL. All the participants were administered 3 doses of booster hepatitis B vaccination (0-1-6 month, 20 µg), and changes in the levels of antibodies were examined at 4 time-points (one month after the first and the third dose, one year and 5 years after the third dose). The seroprotective rate (defined as anti-HBs ≥10.0 mIU/mL) among 225 subjects at the 4 time-points were 93.8%, 100%, 83.6% and 73.4%, respectively (χ

Indexed as

Immunization, SecondaryAdolescentChildChild, PreschoolFemaleHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesHumansMaleTreatment OutcomeHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B Vaccines5-year follow-upanti-HBsbooster vaccinationHBVimmunogenicity effect

Identifiers

PMID27905821
PMCPMC5404365
OpenAlexW2558723961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.