Evidence map›Paper›PMID 27905671›Full record

Trial reportPediatric blood & cancer2017

Long-term survivors of childhood bone and soft tissue sarcomas are at risk of hospitalization.

Cristian D Gonzalez, R Lor Randall, Jennifer Wright, Holly Spraker-Perlman, Jian Ying, Carol Sweeney, Ken R Smith, Anne C Kirchhoff

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Pediatric blood & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cristian D GonzalezUniversity of Utah School of Medicine, Salt Lake City, Utah.
R Lor RandallSarcoma Services, Huntsman Cancer Institute, Salt Lake City, Utah.
Jennifer WrightDepartment of Pediatric Hematology and Oncology, University of Utah, Salt Lake City, Utah.
Holly Spraker-PerlmanDepartment of Pediatric Hematology and Oncology, University of Utah, Salt Lake City, Utah.
Jian YingDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.
Carol SweeneyDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.
Ken R SmithCancer Control and Population Sciences Research Program, Huntsman Cancer Institute, Salt Lake City, Utah.
Anne C KirchhoffDepartment of Pediatric Hematology and Oncology, University of Utah, Salt Lake City, Utah.
University of Utah · USHuntsman Cancer Institute · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
NCI NIH HHS HHSN261201000026CNCI NIH HHS P30 CA042014
6 · The paper itself

Abstract

backgroundChildhood cancer survivors can have a high burden of chronic conditions related to cancer treatment, some of which are debilitating or potentially life-threatening. Much remains to be learned about late effects in bone and soft tissue sarcoma survivors. PROCEDURES: The Utah Cancer Registry was used to identify survivors of bone (N = 71) and soft tissue sarcomas (N = 98) who were diagnosed at ages 0-20 years between 1973 and 2007 and were alive at least 5 years after diagnosis. We selected an age-sex-matched comparison cohort (N = 934). Hospitalizations from 1996 to 2012 were extracted from the Utah Department of Health statewide inpatient hospitalization discharge records. Cox, Poisson, and Gamma regressions were used to evaluate the risk of hospitalization, rate of admission, and length of stay for survivors versus the comparison cohort. Primary ICD-9 codes defined the most common reasons for hospitalizations.

resultsThe hazard ratio (HR) of any hospitalization was higher for survivors in reference to the comparison cohort (HR = 2.12, 95% confidence interval [CI] 1.51-2.97). Survivors experienced more hospital admissions (rate ratio [RR] = 4.58, 95% CI 3.92-5.35) and longer length of stay (RR = 1.28, 95% CI 1.12-1.46) compared with the comparison cohort. Survivors treated with any chemotherapy were at three-fold higher risk (HR = 3.37, 95% CI 1.94-5.83) of hospitalization compared with survivors who received surgery and/or radiation alone. Among hospitalized survivors, the most common reason was injury for bone tumor (26.8%) and neoplasm for soft tissue sarcoma (12.2%).

conclusionChildhood survivors of bone tumor and soft tissue sarcoma face ongoing risk of hospitalization for years after diagnosis.

Indexed as

Bone NeoplasmsHospitalizationRegistriesSarcomaSurvivorsAdolescentAdultChildChild, PreschoolDisease-Free SurvivalFemaleFollow-Up StudiesHumansMaleRisk FactorsSurvival RateAYAbone and soft tissue sarcomachild and adolescent cancersurvivorshipUtah Population Database

Identifiers

PMID27905671
PMCPMC6719692
OpenAlexW2557986030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.