ArticleScientific reports2016
MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer's disease patients.Acta neuropathologica communications · 2026Article
- An AI-guided framework reveals conserved features governing microRNA strand selection.Nucleic acids research · 2026Article
- miRScore: A rapid and precise microRNA validation tool.PLoS computational biology · 2025Article
- Article
- A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis.Nature communications · 2024Article
- Forkhead box O proteins: steering the course of stem cell fate.Cell regeneration (London, England) · 2024Review
- Recent advances in understanding microRNA function and regulation in C. elegans.Seminars in cell & developmental biology · 2024Review
- Article
- MicroRNAs in Age-Related Proteostasis and Stress Responses.Non-coding RNA · 2023Review
- p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress.Communications biology · 2023Article
- Article
- Regulation of vtg and VtgR in mud crab Scylla paramamosain by miR-34.Molecular biology reports · 2022Article
- The Complex Interaction between P53 and miRNAs Joins New Awareness in Physiological Stress Responses.Cells · 2022Review
- The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives.Molecular neurodegeneration · 2021Review
- Parkinson's disease and microRNAs - Lessons from model organisms and human studies.Experimental gerontology · 2021Review
- Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms.Translational psychiatry · 2021Article
- ProbioticFrontiers in cellular and infection microbiology · 2021Article
- miR-421 promotes the viability of A549 lung cancer cells by targeting forkhead box O1.Oncology letters · 2020Article
- MicroRNAs as modulators of longevity and the aging process.Human genetics · 2020Review
- Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk.Aging · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
Diverse stresses and aging alter expression levels of microRNAs, suggesting a role for these posttranscriptional regulators of gene expression in stress modulation and longevity. Earlier studies demonstrated a central role for the miR-34 family in promoting cell cycle arrest and cell death following stress in human cells. However, the biological significance of this response was unclear. Here we show that in C. elegans mir-34 upregulation is necessary for developmental arrest, correct morphogenesis, and adaptation to a lower metabolic state to protect animals against stress-related damage. Either deletion or overexpression of mir-34 lead to an impaired stress response, which can largely be explained by perturbations in DAF-16/FOXO target gene expression. We demonstrate that mir-34 expression is regulated by the insulin signaling pathway via a negative feedback loop between miR-34 and DAF-16/FOXO. We propose that mir-34 provides robustness to stress response programs by controlling noise in the DAF-16/FOXO-regulated gene network.
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