Evidence map›Paper›PMID 27905542›Full record

ArticleScientific reports2016

Defining an olfactory receptor function in airway smooth muscle cells.

William H Aisenberg, Jessie Huang, Wanqu Zhu, Premraj Rajkumar, Randy Cruz, Lakshmi Santhanam, Niranjana Natarajan, Hwan Mee Yong, Breann De Santiago, Jung Jin Oh and 7 more

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Enterochromaffin Cells: Sentinels to Gut Microbiota in Hyperalgesia?Frontiers in cellular and infection microbiology · 2021
    Pooled it
  2. Review
  3. Review
  4. Asthma endotypes and theratypes.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Transcriptomic Changes in Mouse Lung Tissue after a Long-Term Space Flight.Bulletin of experimental biology and medicine · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Bronchomotor tone imbalance evokes airway hyperresponsiveness.Expert review of respiratory medicine · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

William H AisenbergDepartment of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Jessie HuangDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Wanqu ZhuDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Premraj RajkumarDepartment of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Randy CruzDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Lakshmi SanthanamDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Niranjana NatarajanDepartment of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Hwan Mee YongDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Breann De SantiagoDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Jung Jin OhDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
A-Rum YoonDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Reynold A PanettieriInstitute for Translational Medicine and Science, Rutgers University, New Brunswick, NJ 08901, USA.
Oliver HomannGenome Analysis Unit, Amgen Inc., South San Francisco, CA 94080, USA.
John K SullivanDepartment of Inflammation, Amgen Inc., Thousand Oaks, CA 91320, USA.
Stephen B LiggettDepartment of Internal Medicine and Molecular Pharmacology and Physiology, and the Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.
Jennifer L PluznickDepartment of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Steven S AnDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Funding

Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LIGGETT, STEPHEN B · 2013 to 2023
$23.9M
Nrf2 as a critical determinant of smooth muscle functionR01HL107361 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AN, STEVEN S · 2011 to 2015
$2.0M
Uncovering the Functional Role of Olfr78 in Blood Pressure RegulationR01DK107726 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI PLUZNICK, JENNIFER L · 2016 to 2020
$1.8M
MOLECULAR PROPERTIES OF B-ADRENERGIC RECEPTORS IN ASTHMAR01HL045967 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIGGETT, STEPHEN B · 1990 to 2018
$1.3M
NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R01 HL045967NHLBI NIH HHS R01 HL107361NIDDK NIH HHS R01 DK107726
6 · The paper itself

Abstract

Pathways that control, or can be exploited to alter, the increase in airway smooth muscle (ASM) mass and cellular remodeling that occur in asthma are not well defined. Here we report the expression of odorant receptors (ORs) belonging to the superfamily of G-protein coupled receptors (GPCRs), as well as the canonical olfaction machinery (G

Indexed as

Mechanotransduction, CellularAsthmaBronchiHumansMyocytes, Smooth MuscleNeoplasm ProteinsReceptors, OdorantNeoplasm ProteinsOR51E2 protein, humanReceptors, Odorant

Identifiers

PMID27905542
PMCPMC5131280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.