ArticleScientific reports2016
Immune-responsiveness of CD4
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Innate immune response to Streptococcus suis infection: advances and future challenges.Veterinary research · 2026Review
- Review
- Unmutated but T cell dependent IgM antibodies targeting Streptococcus suis play an essential role in bacterial clearance.PLoS pathogens · 2024Article
- Article
- Immunoglobulin M-degrading enzyme ofFrontiers in immunology · 2023Article
- Streptococcus suis Serotype 2 Infection Induces Splenomegaly with Splenocyte Apoptosis.Microbiology spectrum · 2022Article
- Vaccine againstVaccines · 2022Article
- Streptococcus suis Serotype 2 Infection Causes Host Immunomodulation through Induction of Thymic Atrophy.Infection and immunity · 2020Article
- Vaccination with the immunoglobulin M-degrading enzyme ofVaccine: X · 2019Article
- Article
- Pathogen-Reactive T Helper Cell Analysis in the Pig.Frontiers in immunology · 2017Article
- Natural Killer Cell Functions during the Innate Immune Response to Pathogenic Streptococci.Frontiers in microbiology · 2017Article
- Type I Interferon Induced byFrontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The pathogenesis of Streptococcus suis infection, a major swine and human pathogen, is only partially understood and knowledge on the host adaptive immune response is critically scarce. Yet, S. suis virulence factors, particularly its capsular polysaccharide (CPS), enable this bacterium to modulate dendritic cell (DC) functions and potentially impair the immune response. This study aimed to evaluate modulation of T cell activation during S. suis infection and the role of DCs in this response. S. suis-stimulated total mouse splenocytes readily produced TNF-α, IL-6, IFN-γ, CCL3, CXCL9, and IL-10. Ex vivo and in vivo analyses revealed the involvement of CD4
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.