ArticleScientific reports2016
Uterine glands impact uterine receptivity, luminal fluid homeostasis and blastocyst implantation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 97 citations in OpenAlex.
- Luminal epithelium remodeling underlies endometrial regeneration during menstruation and pregnancy.bioRxiv : the preprint server for biology · 2026Article
- Single-cell mapping of human endometrium and decidua reveals epithelial and stromal contributions to fertility.JCI insight · 2026Article
- Maternal diet-induced alterations in uterine fluid sncRNAs compromise preimplantation embryo development and offspring metabolic health.Nature communications · 2025Article
- A bovine 3D endometrium-on-a-chip reveals the role of conceptus-derived proteins, CAPG and PDI, in conceptus-endometrial communication.Biology of reproduction · 2025Article
- Extracellular vesicles, syntaxin 2 and SNAP23 in the uterine microenvironment of the rat.Reproduction (Cambridge, England) · 2025Article
- LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice.Biomolecules · 2025Article
- Progesterone receptor in uterine glands is required for pregnancy establishment in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Structural and Metabolic Changes in Pregnant Rat Uterine and Adipose Tissue Induced by a High-Fat High-Sugar Diet.Biomolecules · 2025Article
- FOXA2 loss results in an increase of endometriosis development and LIF reveals a therapeutic effect for endometriosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
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- Effect ofJournal of veterinary research · 2024Article
- Article
- Amino acid intake strategies define pluripotent cell states.Nature metabolism · 2024Article
- Single-cell insights into epithelial morphogenesis in the neonatal mouse uterus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Estrogen receptor alpha regulates uterine epithelial lineage specification and homeostasis.iScience · 2023Article
- ERK1/2-RSK regulation of oestrogen homeostasis.The FEBS journal · 2023Review
- Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.Scientific reports · 2023Article
- Cysteine dioxygenase and taurine are essential for embryo implantation by involving in EJournal of animal science and biotechnology · 2023Article
- Reliability of Rodent and Rabbit Models in Preeclampsia Research.International journal of molecular sciences · 2022Review
- Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation.Reproductive biology and endocrinology : RB&E · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Uterine glands are essential for pregnancy in mice and likely humans, because they secrete or transport bioactive substances that regulate uterine receptivity for blastocyst implantation. In mice, the uterus becomes receptive to blastocyst implantation on day 4, but is refractory by day 5. Here, blastocysts could be recovered from progesterone-induced uterine gland (PUGKO) but not wildtype (WT) mice on day 5 post-mating. Anti-adhesive Muc1 protein and microvilli were present on the luminal epithelium of PUGKO but not WT uteri. A number of known uterine receptivity genes and gland-specific genes were altered in the PUGKO uterus. Next, the uterus and uterine luminal fluid (ULF) were obtained from WT and PUGKO mice on day 3, 4 and 5. Transcriptome analysis revealed that 580 genes were decreased in the PUGKO uterus, however ULF secrotome analysis revealed that many proteins and several amino acids were increased in the PUGKO ULF. Of note, many proteins encoded by many gland-specific genes were not identified in the ULF of WT mice. These results support the ideas that uterine glands secrete factors that regulate ULF homeostasis and interact with other cell types in the uterus to influence uterine receptivity and blastocyst implantation for the establishment of pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.