ArticleScientific reports2016
High fidelity computational simulation of thrombus formation in Thoratec HeartMate II continuous flow ventricular assist device.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 58 citations in OpenAlex.
- Numerical Analyses of Blood Pumps Under Realistic Operating Conditions.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Computational and Experimental Assessment of Shear-Induced Blood Trauma by HeartMate II, HeartMate 3, and BrioVAD.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Ghost Cells as a Two-Phase Blood Analog Fluid-Optical Thrombus Growth Detection Using Particle Image Velocimetry.Artificial organs · 2025Article
- Influence of LVAD Cannula Outflow Graft Flow Rate and Location on Fluid-Particle Interactions and Thrombi Distribution: A Primary Numerical Study.Journal of cardiovascular translational research · 2024Article
- Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction.Annals of biomedical engineering · 2024Article
- Hemocompatibility and biophysical interface of left ventricular assist devices and total artificial hearts.Blood · 2024Review
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- von Willebrand factor unfolding mediates platelet deposition in a model of high-shear thrombosis.Biophysical journal · 2022Article
- A fibrin enhanced thrombosis model for medical devices operating at low shear regimes or large surface areas.PLoS computational biology · 2022Article
- An Accelerated Thrombosis Model for Computational Fluid Dynamics Simulations in Rotary Blood Pumps.Cardiovascular engineering and technology · 2022Article
- Mathematical and Computational Modeling of Device-Induced Thrombosis.Current opinion in biomedical engineering · 2021Article
- A Continuum Model for the Unfolding of von Willebrand Factor.Annals of biomedical engineering · 2021Article
- Simulation of blood flow in a sudden expansion channel and a coronary artery.Journal of computational and applied mathematics · 2020Article
- Platelet activation via dynamic conformational changes of von Willebrand factor under shear.PloS one · 2020Article
- Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit.Intensive care medicine experimental · 2019Article
- Numerical Simulation of Hemodynamic Changes in Central Veins after Tunneled Cuffed Central Venous Catheter Placement in Patients under Hemodialysis.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Continuous flow ventricular assist devices (cfVADs) provide a life-saving therapy for severe heart failure. However, in recent years, the incidence of device-related thrombosis (resulting in stroke, device-exchange surgery or premature death) has been increasing dramatically, which has alarmed both the medical community and the FDA. The objective of this study was to gain improved understanding of the initiation and progression of thrombosis in one of the most commonly used cfVADs, the Thoratec HeartMate II. A computational fluid dynamics simulation (CFD) was performed using our recently updated mathematical model of thrombosis. The patterns of deposition predicted by simulation agreed well with clinical observations. Furthermore, thrombus accumulation was found to increase with decreased flow rate, and can be completely suppressed by the application of anticoagulants and/or improvement of surface chemistry. To our knowledge, this is the first simulation to explicitly model the processes of platelet deposition and thrombus growth in a continuous flow blood pump and thereby replicate patterns of deposition observed clinically. The use of this simulation tool over a range of hemodynamic, hematological, and anticoagulation conditions could assist physicians to personalize clinical management to mitigate the risk of thrombosis. It may also contribute to the design of future VADs that are less thrombogenic.
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Registered trials
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