ArticleBritish journal of clinical pharmacology2017
Characterization of adverse drug reactions causing admission to an intensive care unit.
Article in British journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Pharmacogenomics and genetic ancestry: an opportunity to transform clinical practice in Colombia.Frontiers in pharmacology · 2026Article
- Causality assessment between reported fatal cerebral haemorrhage and suspected drugs: developing a new algorithm based on the analysis of the Japanese Adverse Event Report (JADER) database and literature review.European journal of clinical pharmacology · 2021Review
- Patient harm from cardiovascular medications.Therapeutic advances in drug safety · 2021Review
- Prevalence and incidence rate of hospital admissions related to medication between 2008 and 2013 in The Netherlands.Pharmacoepidemiology and drug safety · 2020Article
- Applying DoTS adverse drug reactions classification to reports from hospital stimulated reporting.European journal of clinical pharmacology · 2019Article
- Preventability of serious thromboembolic and bleeding events related to the use of oral anticoagulants: a prospective study.British journal of clinical pharmacology · 2018Observational
- Creating and validating a warfarin pharmacogenetic dosing algorithm for Colombian patients.Pharmacogenomics and personalized medicine · 2018Article
- Characterization of adverse drug reactions causing admission to an intensive care unit.British journal of clinical pharmacology · 2017Article
- Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study aimed to determine the occurrence of adverse drug reactions (ADRs) that caused admission to the intensive care unit (ICU) of a university hospital.
methodsClinical records were reviewed for patients meeting the inclusion criteria who were admitted to the ICU between September and December 2012. Suspected cases of ADRs were documented. Nine researchers later evaluated causality using the Naranjo Algorithm, preventability using the Schumock and Thornton criteria, and clinical classification based on the dose-time-susceptibility system.
resultsIn total, 96 patients presented 108 cases of ADR (13.8%, 95% confidence interval 11.2-16.4%) as the cause of admission. The most frequent ADRs were bradyarrhythmias and upper gastrointestinal bleeding (12%). Therapeutic failure accounted for 20%. The most commonly associated medications were acetylsalicylic acid (16%) and losartan (10%). Forty-six cases were categorized as possible, and only one as definite. According to the dose-time-susceptibility classification, in 82% of the cases, the dosage was collateral (within the therapeutic range), and 90% were independent of time; the factors most associated with susceptibility to ADRs were comorbidities (42%) and age (49%). Forty-four percent of the ADRs were considered possibly preventable.
conclusionsADRs contribute significantly to ICU admissions, and a significant number of ADRs are preventable. National studies are needed to assess their incidence and to establish classification standards to reduce their clinical impact.
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