ArticleAnnals of surgical treatment and research2016
Validation of the 7th AJCC/UICC staging system for gastric cancer and a proposal for a new TNM system based on a prognostic score: a retrospective multicenter study.
Article in Annals of surgical treatment and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Delay in diagnosis to treatment and impact on survival of gastric adenocarcinoma in a low income setting without screening facility.Scientific reports · 2023Article
- Immunohistochemical Expression of CDX2 in Gastric Carcinoma.Iranian journal of pathology · 2022Article
- Indications for adjuvant chemotherapy in patients with pT1N1M0 gastric cancer: a single-center experience.Journal of cancer research and clinical oncology · 2021Article
- Prognostic Factors in Stage IB Gastric Cancer after Surgical Resection.Journal of gastric cancer · 2020Article
- Implication of lymph node staging in migration and different treatment strategies for stage T2N0M0 and T1N1M0 resected gastric cancer: a SEER population analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- Comparison of the 7th and the 8th AJCC Staging System for Non-metastatic D2-Resected Lymph Node-Positive Gastric Cancer Treated with Different Adjuvant Protocols.Cancer research and treatment · 2019Article
- Evaluating TNM stage prognostic ability in a population-based cohort of gastric adenocarcinoma patients in a low-incidence country.Canadian journal of public health = Revue canadienne de sante publique · 2018Article
- Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness.Oncology letters · 2018Article
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8 authors.
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Abstract
purposeWe validate the 7th American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system for gastric cancer and propose a new staging system that reflects the prognostic significances of each of T and N category.
methodsData from 5,957 patients who underwent curative gastrectomies from 2000 to 2007 at 4 university hospitals in Daegu Metropolitan city in Korea were analyzed for the validation of the 7th AJCC/UICC staging system for gastric cancer. The hazard ratios of the respective T and N categories were estimated and converted to weightings and summated to make prognostic score (P-score). Homogeneity and stage grouping were determined according to the P-scores.
resultsIn the 7th AJCC/UICC staging system for gastric cancer, poor discrimination was noted between stages IIB and IIIA (P = 0.152). In addition, heterogeneity in stage IIB (P = 0.021) and a small gap in 5-year survival rates (1.7%) between stages IA and IB were noted. A new proposed staging system was generated on the basis of P-scores and demonstrated more discrimination between stages and more homogeneity within stages. The new staging system reflects the different prognostic impacts of N3a and N3b.
conclusionSeveral controversial issues of the 7th AJCC/UICC staging system for gastric cancer were reconfirmed in the present analysis. The TNM system based on P-score appears to be more scientifically accurate than the 7th AJCC/UICC staging system for gastric cancer.
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