Evidence map›Paper›PMID 27904837›Full record

ArticleTranslational cancer research2016

Positron emission tomography/computerized tomography for tumor response assessment-a review of clinical practices and radiomics studies.

Wei Lu, Wengen Chen

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Translational cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05466760 (Use of PET/MR Radiomics to Evaluate the Clinical Phenotypes, Response Status of Neoadjuvant Chemotherapy and Long-term Prognosis of Breast Cancer), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05466760 unknown statusnot on this mapstarted 2018, after this paper: background citation

Use of PET/MR Radiomics to Evaluate the Clinical Phenotypes, Response Status of Neoadjuvant Chemotherapy and Long-term Prognosis of Breast Cancer: a Preliminary Study

Typeobservational_patient_registrySponsorTaipei Veterans General Hospital, TaiwanRan2018 to 2022Enrolled120ConditionsBreast CancerArmsPET/MR
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Value of PET imaging for radiation therapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wei LuDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, USA and Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
Wengen ChenDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, USA.
University of Maryland, Baltimore · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Quantitative PET/CT Analysis to Improve Evaluation of Tumor ResponseR01CA172638 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI LU, WEI · 2013 to 2016
$1.3M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA172638
6 · The paper itself

Abstract

Even with recent advances in cancer diagnosis and therapy, treatment outcomes for many cancers remain dismal. Patients often show different response to the same therapy regimen, supporting the development of personalized medicine. 18F-FDG PET/CT has been used routinely in the assessment of tumor response, in prediction of outcomes, and in guiding personalized treatment. These assessments are mainly based on physician's subjective or semi-quantitative evaluation. Recent development in Radiomics provides a promising objective way for tumor response assessment, which uses computerized tools to extract a large number of image features that capture additional information not currently used in clinic that has prognostic value. In this review, we summarized the clinical use of PET/CT and the PET/CT Radiomics studies for tumor response assessment. Finally, we discussed some challenges and future perspectives.

Indexed as

18F-FDG PET/CTimage analysisRadiomicstumor response

Identifiers

PMID27904837
PMCPMC5124903
OpenAlexW2512672085

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.