ArticleAmerican journal of cancer research2016
Overexpression of YWHAZ as an independent prognostic factor in adenocarcinoma of the esophago-gastric junction.
Article in American journal of cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Exploring 14-3-3ζ: insights into its role in cancer mechanisms and future therapeutic applications.Hereditas · 2026Review
- Pediatric fibromyxoid brachial plexus tumor with YWHAZ::PLAG1 gene fusion: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- A Computational Approach to Justifying Stratifin as a Candidate Diagnostic and Prognostic Biomarker for Pancreatic Cancer.BioMed research international · 2022Article
- hsa-MicroRNA-28-5p Inhibits Diffuse Large B-Cell Lymphoma Cell Proliferation by Downregulating 14-3-3Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Pediatric fibromyxoid soft tissue tumor with PLAG1 fusion: A novel entity?Genes, chromosomes & cancer · 2021Article
- HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma.Thoracic cancer · 2021Article
- YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.International journal of biological sciences · 2021Article
- Loss of miR-204-5p Promotes Tumor Proliferation, Migration, and Invasion Through Targeting YWHAZ/PI3K/AKT Pathway in Esophageal Squamous Cell Carcinoma.OncoTargets and therapy · 2020Article
- MiRNA-802 suppresses proliferation and migration of epithelial ovarian cancer cells by targeting YWHAZ.Journal of ovarian research · 2019Article
- New promising circulating RNA biomarkers for early diagnosis of lung adenocarcinoma.Annals of translational medicine · 2019Article
- Agrin has a pathological role in the progression of oral cancer.British journal of cancer · 2018Article
- 14-3-3ζ Overexpression is Associated with Poor Prognosis in Ovarian Cancer.Yonsei medical journal · 2018Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have demonstrated that YWHAZ (14-3-3ζ), included in the 14-3-3 family of proteins, is implicated in the initiation and progression of cancers. To detect a novel treatment target for adenocarcinoma of the esophagogastric junction (AEG), we tested whether YWHAZ acted as a cancer-promoting gene through its overexpression in AEG. We analyzed YWHAZ protein expression in 92 consecutive primary AEG tumors, which had been curatively resected in our institution between 2000 and 2010. Overexpression of the YWHAZ protein was frequently detected in primary AEG tumor samples (46% (42/92)). Overexpression of YWHAZ was significantly correlated with Siewert type III tumor, larger tumor size (≥40 mm) and higher rates of lymph node metastasis and recurrence. Patients with YWHAZ-overexpressing tumors had a worse overall rate of survival than those with non-expressing tumors (
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27904785PMC5126287W2560020916What OpenQuestion holds
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