ArticleAmerican journal of translational research2016
The central role of HOTAIR in the malignancy of CD44+ human hypopharyngeal carcinoma cells.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Silencing of Long Non-Coding RNA HOTAIR Alleviates Epithelial-Mesenchymal Transition in Pancreatic Cancer via the Wnt/β-Catenin Signaling Pathway.Cancer management and research · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
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Abstract
Human hypopharyngeal carcinoma is one of the most common malignant tumors. CD44 could serve as a molecular marker to screen for cancer stem cells (CSCs) in hypopharyngeal cancer. The aim of this study was to identify the role of HOX transcript antisense RNA (HOTAIR) on cell proliferation and invasion in CD44+ FADU cells (human hypopharyngeal carcinoma cells). We also explored the underlying mechanism contributing to HOTAIR's observed effects. CD44+ FADU cells were sorted and purified by flow cytometry and infected with lentivirus stably expressing HOTAIR shRNA. Cell proliferation and invasion analyses were carried out with cell counting kit-8 (CCK-8) and Transwell assays. The expressions of downstream effectors of HOTAIR, including E-cadherin, β-catenin, and vimentin were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. Knockdown of HOTAIR markedly inhibited the proliferation and invasion of CD44+ FADU cells
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27904706PMC5126348W2560745737What OpenQuestion holds
Registered trials
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