Evidence map›Paper›PMID 27904683›Full record

ArticleAmerican journal of translational research2016

Rapamycin targets Interleukin 6 (IL-6) expression and suppresses endothelial cell invasion stimulated by tumor cells.

Oleksandr Ekshyyan, Alok R Khandelwal, Xiaohua Rong, Tara Moore-Medlin, Xiaohui Ma, Jonathan Steven Alexander, Cherie-Ann O Nathan

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Oleksandr EkshyyanDepartment of Otolaryngology/Head and Neck Surgery, LSUHSCShreveport, LA, USA; Feist-Weiller Cancer Center, LSUHSCShreveport, LA, USA.
Alok R KhandelwalDepartment of Otolaryngology/Head and Neck Surgery, LSUHSCShreveport, LA, USA; Feist-Weiller Cancer Center, LSUHSCShreveport, LA, USA.
Xiaohua RongDepartment of Otolaryngology/Head and Neck Surgery, LSUHSCShreveport, LA, USA; Feist-Weiller Cancer Center, LSUHSCShreveport, LA, USA.
Tara Moore-MedlinDepartment of Otolaryngology/Head and Neck Surgery, LSUHSCShreveport, LA, USA; Feist-Weiller Cancer Center, LSUHSCShreveport, LA, USA.
Xiaohui MaDepartment of Otolaryngology/Head and Neck Surgery, LSUHSCShreveport, LA, USA; Feist-Weiller Cancer Center, LSUHSCShreveport, LA, USA.
Jonathan Steven AlexanderDepartment of Cellular and Molecular Physiology, LSUHSC Shreveport, LA, USA.
Cherie-Ann O NathanDepartment of Otolaryngology/Head and Neck Surgery, LSUHSCShreveport, LA, USA; Feist-Weiller Cancer Center, LSUHSCShreveport, LA, USA.
Louisiana State University Health Sciences Center New Orleans · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

mTOR inhibitors have potent antiangiogenic and anti-lymphangiogenic effects in addition to their growth inhibitory effects in head and neck squamous cell carcinoma (HNSCC). Lymphatogenous spread is much more predominant in HNSCC than hematogenous spread and significantly decreases survival. In this study we evaluated the effects of rapamycin on targeting tumor-stroma crosstalk in HNSCC. HNSCC tumor cells (FaDu) and human lymphatic endothelial cells (HMEC-1A) were co-cultured in various combinations using transwell cell culture inserts to study tumor-stroma crosstalk and the effects of mTOR inhibitor rapamycin. Levels of growth factors and cytokines in cell culture media were measured using Milliplex bead immunoassay (EMD Millipore) and ELISA assay (R&D Systems). We found that conditioned media collected from tumor cells or co-culture with tumor cells significantly increased the invasiveness of lymphatic and blood vascular endothelial cells (

Indexed as

crosstalkHead and neck squamous cell carcinomaInterleukin-6lymphangiogenesismTOR inhibitors

Identifiers

PMID27904683
PMCPMC5126325
OpenAlexW2559817919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.