ArticleIranian journal of nursing and midwifery research
A survey of the therapeutic effects of Vitamin E suppositories on vaginal atrophy in postmenopausal women.
Article in Iranian journal of nursing and midwifery research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review.Nutrients · 2022Pooled it
- Interventions Preventing Vaginitis, Vaginal Atrophy after Brachytherapy or Radiotherapy Due to Malignant Tumors of the Female Reproductive Organs-A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- VagiBIOM Lactobacillus suppository improves vaginal health index in perimenopausal women with bacterial vaginosis: a randomized control trial.Scientific reports · 2024Trial
- The effect of oxytocin vaginal gel on vaginal atrophy in postmenopausal women: a randomized controlled trial.BMC women's health · 2020Trial
- Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial.International urogynecology journal · 2019Trial
- Mitochondrial dysfunction in perimenopausal mood disorders: From hormonal shifts to neuroenergetic failure (Review).International journal of molecular medicine · 2025Review
- Retrospective Investigator-Initiated Trial on Tocopherol Acetate Vaginal Administration in Pre-and Postmenopausal Women.Diseases (Basel, Switzerland) · 2024Article
- Gut microbiota affects the estrus return of sows by regulating the metabolism of sex steroid hormones.Journal of animal science and biotechnology · 2023Article
- Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials.Journal of menopausal medicine · 2022Review
- A Review of Pharmacological Treatments for Vaginal Atrophy in Postmenopausal Women in Iran.Journal of menopausal medicine · 2020Review
- Optimization of a Vaginal Suppository Formulation to Deliver SHetA2 as a Novel Treatment for Cervical Dysplasia.Journal of pharmaceutical sciences · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMenopause is associated with various complications such as depression, sleep disorders, and genitourinary atrophy. Vaginal atrophy occurs due to the loss of steroid hormones, and its major symptoms include vaginal dryness, itching, dyspareunia, and bleeding after intercourse. According to the literature, vitamin E plays a key role in estrogen stability. The aim of this study was to compare the effects of vitamin E suppositories and conjugated estrogen vaginal cream on vaginal atrophy. MATERIALS AND
methodsIn this clinical trial, 52 postmenopausal women, who were referred to a gynecology clinic in 2013, were recruited and randomly divided into two groups (26 cases per group). One group received 100 IU of vitamin E suppositories (
resultsThe mean VMV in the vitamin E group before the treatment and after 4, 8, and 12 weeks of treatment was 43.78 ± 13.75, 69.07 ± 22.75, 77.86 ± 21.79, and 80.59 ± 19.23, respectively. The corresponding values in the estrogen cream group were 42.86 ± 14.40, 86.98 ± 12.58, 92.65 ± 15, and 91.57 ± 14.10, respectively. VMV significantly improved in both the treatment groups after the intervention, compared to the preintervention period (
conclusionsBased on the findings, use of vitamin E suppositories could improve the laboratory criteria for vaginal atrophy and treatment success. Therefore, vitamin E suppositories are suggested for relieving the symptoms of vaginal atrophy, especially in women who are unable to use hormone therapy or cope with the associated side effects.
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