ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2017
Identification and validation of clinically meaningful benchmarks in the 12-item Multiple Sclerosis Walking Scale.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06486116 (Effectiveness of Task Specific Home Exercise Program), which is not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Task Specific Home Exercise Program
Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Randomized controlled trial of a remotely-delivered exercise training program in older adults with multiple sclerosis: Secondary effects on cognition, symptoms, and quality of life.Multiple sclerosis and related disorders · 2026Trial
- Remotely-delivered exercise training program among older adults with multiple sclerosis: Feasibility results of a randomized controlled trial.Contemporary clinical trials · 2026Trial
- Pulse Width Does Not Influence the Gains Achieved With Neuromuscular Electrical Stimulation in People With Multiple Sclerosis: Double-Blind, Randomized Trial.Neurorehabilitation and neural repair · 2018Trial
- Measuring health-related quality of life in multiple sclerosis: comparing the acceptability, validity and responsiveness of the EQ-5D-3L and MSIS-8D.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Reliability and validity of the 12-item multiple sclerosis walking scale in adults with chronic cervical or thoracic incomplete spinal cord injury.Spinal cord · 2026Article
- Article
- Validating wearable step counts in multiple sclerosis research: a replication study.Frontiers in neurology · 2025Article
- Quality of reporting health behaviors for multiple sclerosis (QuoRH-MS): A scoping review to inform intervention planning and improve consistency of reporting.Brain and behavior · 2024Article
- Propulsive Force Modulation Drives Split-Belt Treadmill Adaptation in People with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2024Article
- Article
- Translation and validation of the multiple sclerosis walking scale 12 for the German population - the MSWS-12/D.Health and quality of life outcomes · 2023Article
- Fall Assessment and Monitoring in People With Multiple Sclerosis: A Practical Evidence-Based Review for Clinicians.Neurology. Clinical practice · 2023Article
- Split-Belt Treadmill Adaptation Improves Spatial and Temporal Gait Symmetry in People with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2023Article
- Mediterranean diet is linked to less objective disability in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Progression events defined by home-based assessment of motor function in multiple sclerosis: protocol of a prospective study.Frontiers in neurology · 2023Article
- Non-equivalent, but still valid: Establishing the construct validity of a consumer fitness tracker in persons with multiple sclerosis.PLOS digital health · 2023Article
- Identifying falls remotely in people with multiple sclerosis.Journal of neurology · 2022Article
- Methodological heterogeneity biases physical activity metrics derived from the Actigraph GT3X in multiple sclerosis: A rapid review and comparative study.Frontiers in rehabilitation sciences · 2022Article
- The Role of Remote Monitoring in Evaluating Fatigue in Multiple Sclerosis: A Review.Frontiers in neurology · 2022Review
- Cognitive Processing Speed Impairment Does Not Influence the Construct Validity of Six-Spot Step Test Performance in People With Multiple Sclerosis.Physical therapy · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe 12-item Multiple Sclerosis Walking Scale (12-MSWS) is a validated questionnaire which assessed walking function; it has been widely adopted in multiple sclerosis (MS) clinical research.
objectiveIdentify and validate clinically meaningful 12-MSWS benchmarks in MS.
methodsCross-sectional study of 159 MS patients permitted identification of clinically meaningful 12-MSWS benchmarks based on their relationship to real-life anchors. Identified 12-MSWS benchmarks were then validated in a second population of 96 subjects using measures of ambulation, cognition, and patient-reported outcomes.
results12-MSWS score of 0-24.99 was associated with working outside the home and assistance-free mobility; 25-49.99 was associated with gait disability and difficulty doing housework; 50-74.99 was associated with unemployment, government healthcare, cane use, and difficulty performing instrumental activities of daily living (IADLs); and 75-100 was associated with change in occupation due to walking, mobility impairment requiring bilateral assistance, and inability to perform IADLs. During the validation step, strong linear associations were identified between 12-MSWS benchmarks and other MS-related disability outcome measures, including ambulatory and non-ambulatory measures.
conclusionWe have identified clinically meaningful 12-MSWS benchmarks which define four groups differentiated by increasing levels of mobility impairment and associated loss of functional independence. These data provide insight into how 12-MSWS translate to meaningful functional limitations in MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.