ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2017
Impairment of decision-making in multiple sclerosis: A neuroeconomic approach.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Factors interfering with parenthood decision-making in an Italian sample of people with multiple sclerosis: an exploratory online survey.Journal of neurology · 2019Article
- Principles of Economic Rationality in Mice.Scientific reports · 2017Article
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Authors and funding
11 authors.
Funding
Abstract
objectiveTo assess the decision-making impairment in patients with multiple sclerosis (MS) and how they relate to other cognitive domains.
methodsWe performed a cross-sectional analysis in 84 patients with MS, and 21 matched healthy controls using four tasks taken from behavioral economics: (1) risk preferences, (2) choice consistency, (3) delay of gratification, and (4) rate of learning. All tasks were conducted using real-world reward outcomes (food or money) in different real-life conditions. Participants underwent cognitive examination using the Brief Repeatable Battery-Neuropsychology.
resultsPatients showed higher risk aversion (general propensity to choose the lottery was 0.51 vs 0.64, p = 0.009), a trend to choose more immediate rewards over larger but delayed rewards ( p = 0.108), and had longer reactions times ( p = 0.033). Choice consistency and learning rates were not different between groups. Progressive patients chose slower than relapsing patients. In relation to general cognitive impairments, we found correlations between impaired decision-making and impaired verbal memory ( r = 0.29, p = 0.009), visual memory ( r = -0.37, p = 0.001), and reduced processing speed ( r = -0.32, p = 0.001). Normalized gray matter volume correlated with deliberation time ( r = -0.32, p = 0.005).
conclusionPatients with MS suffer significant decision-making impairments, even at the early stages of the disease, and may affect patients' quality and social life.
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