ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2017
Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Decoding Thalamic Glial Interplay in Multiple Sclerosis Through Proton Magnetic Resonance Spectroscopy and Positron Emission Tomography.International journal of molecular sciences · 2025Article
- Serum glial fibrillary acid protein associates with TSPO-expressing lesions in multiple sclerosis brain.Therapeutic advances in neurological disorders · 2025Article
- Does seasonal variation affect the neuroimmune system? A retrospective [Neuroscience letters · 2024Article
- Evaluation of microglia activation related markers following a clinical course of TBS: A non-human primate study.PloS one · 2024Article
- Corneal immune cells as a biomarker of inflammation in multiple sclerosis: a longitudinal study.Therapeutic advances in neurological disorders · 2023Article
- The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic.Brain, behavior, and immunity · 2022Article
- Assessment ofDiagnostics (Basel, Switzerland) · 2021Article
- PET imaging of P2XJournal of neuroinflammation · 2020Article
- The Role of Microglia in Perioperative Neurocognitive Disorders.Frontiers in cellular neuroscience · 2020Review
- A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis.Brain : a journal of neurology · 2019Article
- Chronic inflammation in multiple sclerosis - seeing what was always there.Nature reviews. Neurology · 2019Review
- Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.Molecular neuropsychiatry · 2019Review
- PET Evaluation of Microglial Activation in Non-neurodegenerative Brain Diseases.Current neurology and neuroscience reports · 2019Review
- Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers.EJNMMI radiopharmacy and chemistry · 2019Review
- Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in.Translational neurodegeneration · 2019Review
- Quantifying the Metabolic Signature of Multiple Sclerosis byFrontiers in neurology · 2019Review
- Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge-Preliminary findings.PloS one · 2019Article
- Evaluation of Microglial Activation in Multiple Sclerosis Patients Using Positron Emission Tomography.Frontiers in neurology · 2018Review
- The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases.International journal of molecular sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMultiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this.
objectiveTo explore the in vivo relationships between MRS and PET [
methodsA total of 23 patients were studied. TSPO PET imaging with [
results[
conclusionMRS [ myo-inositol] and PET [
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.