Evidence map›Paper›PMID 27903914›Full record

ArticleNucleic acids research2017

Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.

Leo C K Wan, Pierre Maisonneuve, Rachel K Szilard, Jean-Philippe Lambert, Timothy F Ng, Noah Manczyk, Hao Huang, Rob Laister, Amy A Caudy, Anne-Claude Gingras and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 64 citations in OpenAlex.

  1. Catalytic and regulatory basis of tRNA tNature communications · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Genetics and phenotypic heterogeneity of Galloway-Mowat syndrome.Cell communication and signaling : CCS · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Case Report: Novel compound heterozygousFrontiers in pediatrics · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. NovelFrontiers in molecular neuroscience · 2023
    Article
  17. Article
  18. Conservation and Diversification of tRNA tInternational journal of molecular sciences · 2022
    Review
  19. Nuclear Functions of KaeA, a Subunit of the KEOPS Complex inInternational journal of molecular sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Leo C K WanLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Pierre MaisonneuveLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Rachel K SzilardLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Jean-Philippe LambertLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Timothy F NgLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Noah ManczykLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Hao HuangLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Rob LaisterSchool of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzen, 518055, China.
Amy A CaudyDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Daniel DurocherLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada durocher@lunenfeld.ca.
Frank SicheriLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada sicheri@lunenfeld.ca.
Lunenfeld-Tanenbaum Research Institute · CAMount Sinai Hospital · CAUniversity of Toronto · CAPeking University · CNPrincess Margaret Cancer Centre · CA

Funding

CIHR FDN 143277CIHR FDN 143301CIHR FDN 143343
6 · The paper itself

Abstract

The KEOPS/EKC complex is a tRNA modification complex involved in the biosynthesis of N

Indexed as

Multiprotein ComplexesOpen Reading FramesProtein SubunitsProteomicsAmino Acid SequenceCell LineHumansIntrinsically Disordered ProteinsProtein Interaction MappingProtein Interaction MapsSaccharomyces cerevisiae ProteinsIntrinsically Disordered ProteinsKEOPS complex, S cerevisiaeMultiprotein ComplexesProtein SubunitsSaccharomyces cerevisiae Proteins

Identifiers

PMID27903914
PMCPMC5314774
OpenAlexW2557785875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.