ArticleThe Journal of nutrition2017
Early-Life Sugar Consumption Affects the Rat Microbiome Independently of Obesity.
Article in The Journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03543644 (A Randomized Controlled Trial of the Effect of Replacing Sugar-sweetened Beverages With Non-nutritive Sweetened Beverages or Water on Gut Microbiome and Metabolic Outcomes), which is not on this map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of the Effect of Replacing Sugar-sweetened Beverages With Non-nutritive Sweetened Beverages or Water on Gut Microbiome and Metabolic Outcomes: STOP Sugars NOW Trial
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MNEMONIC: MetageNomic Experiment Mining to create an OTU Network of Inhabitant Correlations.BMC bioinformatics · 2019Pooled it
- Associations of Dietary Intake with the Intestinal Microbiota and Short-Chain Fatty Acids Among Young Adults with Type 1 Diabetes and Overweight or Obesity.The Journal of nutrition · 2023Trial
- Characterization of the Stool Microbiome in Hispanic Preschool Children by Weight Status and Time.Childhood obesity (Print)Trial
- Diet, gut microbiome, and type 1 diabetes: from risk to translational opportunity.Gut microbes · 2026Review
- Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.Gut microbes · 2026Review
- Exploratory metabolomic profiling reveals metabolic alterations potentially associated with pain and blood pressure regulation in a high-sugar diet rat model.Scientific reports · 2026Article
- Gut Microbiome Dynamics in Food Allergy Development Across the Lifespan: Microbial Mechanisms, Host Interactions, and Therapeutic Perspectives.Microorganisms · 2026Review
- Maternal cafeteria diet and methyl donor supplementation modulate gut microbiota and anxiety-like behavior in male offspring.Food & nutrition research · 2026Article
- Dietary Habits and Their Influence on the Microbiome and Mental Health in Adolescents.Nutrients · 2025Review
- Exposure to sugar rationing in the first 1000 days of life protected against chronic disease.Science (New York, N.Y.) · 2024Article
- Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling.Brain, behavior, and immunity · 2024Article
- Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats.Appetite · 2024Article
- SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats.Chronobiology international · 2024Article
- Review
- Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling.bioRxiv : the preprint server for biology · 2023Article
- Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration.Scientific reports · 2023Article
- Early-life influences of low-calorie sweetener consumption on sugar taste.Physiology & behavior · 2023Review
- The gut microbiome in social anxiety disorder: evidence of altered composition and function.Translational psychiatry · 2023Article
- Associations of disordered eating with the intestinal microbiota and short-chain fatty acids among young adults with type 1 diabetes.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2023Article
- Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe gut microbiome has been implicated in various metabolic and neurocognitive disorders and is heavily influenced by dietary factors, but there is a paucity of research on the effects of added sugars on the gut microbiome.
objectiveWith the use of a rodent model, our goal was to determine how added-sugar consumption during the juvenile and adolescent phase of development affects the gut microbiome.
methodsForty-two juvenile male Sprague-Dawley rats [postnatal day (PND) 26; 50-70 g] were given access to 1 of 3 different 11%-carbohydrate solutions designed to model a range of monosaccharide ratios commonly consumed in sugar-sweetened beverages: 1) 35% fructose:65% glucose, 2) 50% fructose:50% glucose, 3) 65% fructose:35% glucose, and 4) control (no sugar). After ad libitum access to the respective solutions for the juvenile and adolescent period (PND 26-80), fecal samples were collected for next-generation 16S ribosomal RNA sequencing and multivariate microbial composition analyses. Energy intake, weight change, and adiposity index were analyzed in relation to sugar consumption and the microbiota.
resultsBody weight, adiposity index, and total caloric intake did not differ as a result of sugar consumption. However, sugar consumption altered the gut microbiome independently of anthropometric measures and caloric intake. At the genus level, Prevotella [linear discriminant analysis (LDA) score = -4.62; P < 0.001] and Lachnospiraceae incertae sedis (LDA score = -3.01; P = 0.03) were reduced, whereas Bacteroides (LDA score = 4.19; P < 0.001), Alistipes (LDA score = 3.88; P < 0.001), Lactobacillus (LDA score = 3.78; P < 0.001), Clostridium sensu stricto (LDA score = 3.77; P < 0.001), Bifidobacteriaceae (LDA score = 3.59; P = 0.001), and Parasutterella (LDA score = 3.79; P = 0.004) were elevated by sugar consumption. No overall pattern could be attributable to monosaccharide ratio.
conclusionsEarly-life sugar consumption affects the gut microbiome in rats independently of caloric intake, body weight, or adiposity index; these effects are robust across a range of fructose-to-glucose ratios.
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Registered trials
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