Evidence map›Paper›PMID 27903817›Full record

ArticleNeurology2017

Effects of orthostatic hypotension on cognition in Parkinson disease.

Justin Centi, Roy Freeman, Christopher H Gibbons, Sandy Neargarder, Alexander O Canova, Alice Cronin-Golomb

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05400174 narecruitingnot on this mapstarted 2021, after this paper: background citation

Effects of Blood Pressure on Cognition and Cerebral Blood Flow in Parkinson Disease

TypeinterventionalSponsorUniversity of California, San DiegoRan2021 to 2027Enrolled60ConditionsParkinson Disease, Orthostatic Hypotension, DysautonomiaArmsTilt table (upright position)
NCT06252376 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in Parkinson's Disease

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2029Enrolled0ConditionsParkinson Disease, Orthostatic Hypertension, Cognitive Change, Cognitive ImpairmentArmsHead-up tilt table
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  3. Orthostatic hypotension and acute cognitive dysfunction in Parkinson's disease: insights from functional near-infrared spectroscopy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Article
  4. Review
  5. Autonomic debate: symptoms are an optimal target for orthostatic hypotension screening and management. An argument in opposition.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Justin CentiFrom the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
Roy FreemanFrom the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
Christopher H GibbonsFrom the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
Sandy NeargarderFrom the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
Alexander O CanovaFrom the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
Alice Cronin-GolombFrom the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA. alicecg@bu.edu.

Funding

Training CoreU54NS065736 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROBERTSON, DAVID HERLIE · 2009 to 2018
$11.6M
Effects of Parkinson's Disease on Perception, Cognition, and GaitR01NS067128 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CRONIN-GOLOMB, ALICE · 2009 to 2013
$3.2M
FASEB SRC on ION CHANNEL REGULATIONR13NS074801 · NINDS · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · PI GEORGE, ALFRED L. · 2011 to 2011
$20k
NINDS NIH HHS R01 NS067128NINDS NIH HHS R13 NS074801NINDS NIH HHS U54 NS065736
6 · The paper itself

Abstract

objectiveTo investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in Parkinson disease (PD) using a cross-sectional and within-group design.

methodsIndividuals without dementia with idiopathic PD included 18 with OH (PDOH) and 19 without OH; 18 control participants were also included. Neuropsychological tests were conducted in supine and upright-tilted positions. Blood pressure was assessed in each posture.

resultsThe PD groups performed similarly while supine, demonstrating executive dysfunction in sustained attention and response inhibition, and reduced semantic fluency and verbal memory (encoding and retention). Upright posture exacerbated and broadened these deficits in the PDOH group to include phonemic fluency, psychomotor speed, and auditory working memory. When group-specific supine scores were used as baseline anchors, both PD groups showed cognitive changes following tilt, with the PDOH group exhibiting a wider range of deficits in executive function and memory as well as significant changes in visuospatial function.

conclusionsCognitive deficits in PD have been widely reported with assessments performed in the supine position, as seen in both our PD groups. Here we demonstrated that those with PDOH had transient, posture-mediated changes in excess of those found in PD without OH. These observed changes suggest an acute, reversible effect. Understanding the effects of OH due to autonomic failure on cognition is desirable, particularly as neuroimaging and clinical assessments collect data only in the supine or seated positions. Identification of a distinct neuropsychological profile in PD with OH has quality of life implications, and OH presents itself as a possible target for intervention in cognitive disturbance.

Indexed as

AgedAttentionBlood PressureCognition DisordersCross-Sectional StudiesExecutive FunctionFemaleHeart RateHumansHypotension, OrthostaticMaleMemoryMiddle AgedNeuropsychological TestsParkinson DiseasePosture

Identifiers

PMID27903817
PMCPMC5200856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.