Evidence map›Paper›PMID 27903737›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells.

Tibor Z Veres, Tamás Kopcsányi, Nicholas van Panhuys, Michael Y Gerner, Zhiduo Liu, Pia Rantakari, Johannes Dunkel, Masayuki Miyasaka, Marko Salmi, Sirpa Jalkanen and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. The genetics of hyper IgE syndromes.Frontiers in immunology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. CXCL10Cell reports · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 4 countries.

Tibor Z VeresMediCity Research Laboratory, University of Turku, 20520 Turku, Finland; tibor.veres@utu.fi rgermain@nih.gov.ORCID 0000-0002-6980-8900
Tamás KopcsányiMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.
Nicholas van PanhuysLymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Michael Y GernerLymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Zhiduo LiuLymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Pia RantakariMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.ORCID 0000-0003-1638-5075
Johannes DunkelMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.
Masayuki MiyasakaMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.ORCID 0000-0001-6122-5201
Marko SalmiMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.
Sirpa JalkanenMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.
Ronald N GermainLymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; tibor.veres@utu.fi rgermain@nih.gov.
University of Turku · FINational Institutes of Health · US

Funding

Multiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4M
Functional Biology Of T CellsZIAAI000758 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$15.4M
Multiscale Analysis of Immune ResponsesZ01AI000545 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI GERMAIN, RONALD N · 1990 to 2008
$4.5M
Intramural NIH HHS Z01 AI000545
6 · The paper itself

Abstract

Allergic asthma develops in the mucosal tissue of small bronchi. At these sites, local cytokine production by Th2/Th17 cells is believed to be critical for the development of tissue eosinophilia/neutrophilia. Using the mouse trachea as a relevant model of human small airways, we performed advanced in vivo dynamic and in situ static imaging to visualize individual cytokine-producing T cells in the airway mucosa and to define their immediate cellular environment. Upon allergen sensitization, newly recruited CD4

Indexed as

Adoptive TransferAnimalsAsthmaCD4-Positive T-LymphocytesChemotaxis, LeukocyteCytokinesDendritic CellsDisease Models, AnimalFemaleFlow CytometryHypersensitivityImmunity, MucosalImmunohistochemistryMaleMiceMicroscopy, ConfocalCytokines

Identifiers

PMID27903737
PMCPMC5225021
OpenAlexW2558664725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.