Evidence map›Paper›PMID 27903712›Full record

ReviewHaematologica2016

The myeloma stem cell concept, revisited: from phenomenology to operational terms.

Hans Erik Johnsen, Martin Bøgsted, Alexander Schmitz, Julie Støve Bødker, Tarec Christoffer El-Galaly, Preben Johansen, Peter Valent, Niklas Zojer, Els Van Valckenborgh, Karin Vanderkerken and 5 more

Abstract readReview
In one paragraph

Review in Haematologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hans Erik JohnsenDepartment of Haematology Aalborg University Hospital, Denmark haej@rn.dk.
Martin BøgstedDepartment of Haematology Aalborg University Hospital, Denmark.
Alexander SchmitzDepartment of Haematology Aalborg University Hospital, Denmark.
Julie Støve BødkerDepartment of Haematology Aalborg University Hospital, Denmark.
Tarec Christoffer El-GalalyDepartment of Haematology Aalborg University Hospital, Denmark.
Preben JohansenDepartment of Hematopathology, Aalborg University Hospital, Denmark.
Peter ValentThe Department of Internal Medicine I, Division of Hematology Medical University of Vienna, Austria.
Niklas ZojerWilhelminen Cancer Research Institute and Ludwig Boltzmann Cluster Oncology, First Department of Medicine, Center for Oncology and Hematology, Vienna, Austria.
Els Van ValckenborghDepartment of Hematology and Immunology-Myeloma Center, Vrije University Brussels, Belgium.
Karin VanderkerkenDepartment of Hematology and Immunology-Myeloma Center, Vrije University Brussels, Belgium.
Mark van DuinDepartment of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
Pieter SonneveldDepartment of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
Martin Perez-AndresDepartment of Medicine and Cytometry Service (NUCLEUS), Cancer Research Center (IBMCC, USAL-CSIC), Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca (USAL), Spain.
Alberto OrfaoDepartment of Medicine and Cytometry Service (NUCLEUS), Cancer Research Center (IBMCC, USAL-CSIC), Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca (USAL), Spain.
Karen DybkærDepartment of Haematology Aalborg University Hospital, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of the myeloma stem cell may have important therapeutic implications, yet its demonstration has been hampered by a lack of consistency in terms and definitions. Here, we summarize the current documentation and propose single-cell in vitro studies for future translational studies. By the classical approach, a CD19

Indexed as

AnimalsAntineoplastic AgentsBiomarkersB-LymphocytesCell PlasticityCell Self RenewalDrug Resistance, NeoplasmGenetic VariationHumansMultiple MyelomaNeoplastic Stem CellsPhenotypeAntineoplastic AgentsBiomarkers

Identifiers

PMID27903712
PMCPMC5479618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.