ArticleThe Journal of biological chemistry2017
The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Temporal phosphoproteomics reveals key regulators of procoagulant COAT platelet generation.Blood vessels, thrombosis & hemostasis · 2026Article
- Reconstitution of Ras-PI3Kγ membrane communication and feedback using light-induced signaling inputs.Nature communications · 2026Article
- A Rasa3-Gαi signaling axis orchestrates B lymphocyte trafficking into and through lymphoid organs.Cell reports · 2026Article
- Review
- Modeling platelet P2YBiophysical journal · 2025Article
- Roles of G proteins and their GTPase-activating proteins in platelets.Bioscience reports · 2024Review
- Inositol 1,3,4,5-tetrakisphosphate: a remarkable second messenger in platelet signaling.Research and practice in thrombosis and haemostasis · 2024Article
- Evidence that inositol 1,4,5-trisphosphate 3-kinase and inositol 1,3,4,5-tetrakisphosphate are negative regulators of platelet function.Research and practice in thrombosis and haemostasis · 2024Article
- Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion.Trends in immunology · 2023Review
- The relative importance of platelet integrins in hemostasis, thrombosis and beyond.Haematologica · 2023Review
- Preeclampsia: Platelet procoagulant membrane dynamics and critical biomarkers.Research and practice in thrombosis and haemostasis · 2023Article
- SHIP1 Controls Internal Platelet Contraction and αInternational journal of molecular sciences · 2023Article
- GRK2 regulates ADP signaling in platelets via P2Y1 and P2Y12.Blood advances · 2022Article
- A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells.Science signaling · 2022Article
- Class I PI3K Biology.Current topics in microbiology and immunology · 2022Article
- Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis.International journal of molecular sciences · 2021Article
- Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.Scientific reports · 2021Article
- PI3K in T Cell Adhesion and Trafficking.Frontiers in immunology · 2021Review
- Visualization of integrin molecules by fluorescence imaging and techniques.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2021Article
- Extract of SeaweedFrontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Anthony M BattramFrom the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Tom N DurrantFrom the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Ejaife O AgbaniFrom the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Kate J HeesomSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, United Kingdom.
David S Paulthe McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.
Raymond Piattthe McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.
Alastair W PooleFrom the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Peter J CullenSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Wolfgang Bergmeierthe McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.
Samantha F MooreFrom the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Ingeborg HersFrom the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom. Electronic address: i.hers@bristol.ac.uk.
University of Bristol · GBUniversity of North Carolina at Chapel Hill · US
Funding
Spatial regulation of platelet activation by Podoplanin-Clec2 signalingR01HL121650 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BERGMEIER, WOLFGANG, KAHN, MARK L · 2014 to 2017
$1.2MBritish Heart Foundation FS/12/22/29510British Heart Foundation PG/12/79/29884British Heart Foundation PG/13/11/30016British Heart Foundation PG/14/3/30565British Heart Foundation PG/16/21/32083British Heart Foundation PG/16/3/31833British Heart Foundation RG/10/006/28299British Heart Foundation RG/15/16/31758Medical Research Council MR/P018807/1NHLBI NIH HHS R01 HL121650
Abstract
The class I PI3K family of lipid kinases plays an important role in integrin α
Indexed as
Amino Acid SubstitutionAnimalsBlood PlateletsCHO CellsCricetinaeCricetulusDisease Models, AnimalGTPase-Activating ProteinsHumansMiceMice, Mutant StrainsMutation, MissensePhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPlatelet Glycoprotein GPIIb-IIIa ComplexReceptors, Cytoplasmic and NuclearGTPase-Activating Proteinsinositol-1,3,4,5-tetrakisphosphate receptorphosphatidylinositol 3,4,5-triphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPlatelet Glycoprotein GPIIb-IIIa ComplexRAP1GAP protein, humanRap1GAP protein, mouseRASA3 protein, mouseReceptors, Cytoplasmic and Nuclearcell signalingGAP1IP4BPintegrinphosphatidylinositide 3-kinase (PI3K)plateletRasa3Ras-related protein 1 (Rap1)
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LicenceCC BY
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.