ArticleBMJ open2016
Commonly prescribed drugs associate with cognitive function: a cross-sectional study in UK Biobank.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Effect of Ibuprofen on BrainAGE: A Randomized, Placebo-Controlled, Dose-Response Exploratory Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Trial
- Association of Bisphosphonate Use With Risks of Knee Osteoarthritis and Total Knee Replacement: Population-Based Cohort Study.International journal of rheumatic diseases · 2026Article
- The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Associations of potentially inappropriate medications in older adults with mortality and hospitalizations: methodological challenges in pharmacoepidemiology.European journal of epidemiology · 2025Article
- The Role of Oxidative Stress and Inflammation in the Pathogenesis and Treatment of Vascular Dementia.Cells · 2025Review
- Analysis of postmarketing neuropsychiatric adverse events of avapritinib based on the FDA adverse event reporting system.Scientific reports · 2025Article
- LiveDrive AI: A Pilot Study of a Machine Learning-Powered Diagnostic System for Real-Time, Non-Invasive Detection of Mild Cognitive Impairment.Bioengineering (Basel, Switzerland) · 2025Article
- The Cognitive Footprint of Medication Use.Brain and behavior · 2025Article
- Psychometric Evaluation of a Tablet-Based Tool to Detect Mild Cognitive Impairment in Older Adults: Mixed Methods Study.Journal of medical Internet research · 2024Article
- Association between 19 medication use and risk of common cancers: A cross-sectional and Mendelian randomisation study.Journal of global health · 2024Article
- Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor.Clinical kidney journal · 2023Review
- Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population.Alzheimer's research & therapy · 2023Article
- Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study.BMC medicine · 2023Article
- Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol.Translational stroke research · 2022Article
- Validation of UK Biobank data for mental health outcomes: A pilot study using secondary care electronic health records.International journal of medical informatics · 2022Article
- Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults.PloS one · 2022Article
- Gastric acid suppressants and cognitive decline in people with or without cognitive impairment.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Lack of association between proton pump inhibitor use and decline in cognitive performance in the ELSA-Brasil cohort.European journal of clinical pharmacology · 2021Article
- Elevated anxiety, hypoactivity, memory deficits, decreases of brain serotonin and 5-HT-1A receptors expression in rats treated with omeprazole.Toxicological research · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo investigate medications associated with cognitive function.
designPopulation-based cross-sectional cohort study.
settingUK Biobank.
participantsUK Biobank participants aged 37-73 years who completed cognitive tests at the baseline visit in 2006-2010.
main outcome measuresCognitive test outcomes on verbal-numerical reasoning test (n=165 493), memory test (n=482 766) and reaction time test (n=496 813).
resultsMost drugs (262 of 368) were not associated with any cognitive tests after adjusting for age, gender, education, household income, smoking, alcohol status, psychostimulant/nootropic medication use, assessment centre, and concurrent diagnoses and medications. Drugs used for nervous system disorders were associated with poorer cognitive performance (antiepileptics, eg, topiramate b
conclusionsIn this large volunteer study, some commonly prescribed medications were associated with poor cognitive performance. Some associations may reflect underlying diseases for which the medications were prescribed, although the analysis controlled for the possible effect of diagnosis. Other drugs, whose association cannot be linked to the effect of any disease, may need vigilance for their implications in clinical practice.
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