Evidence map›Paper›PMID 27903535›Full record

ArticleCirculation. Cardiovascular imaging2016

Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart Muscles.

Xulei Qin, Johannes Riegler, Malte Tiburcy, Xin Zhao, Tony Chour, Babacar Ndoye, Michael Nguyen, Jackson Adams, Mohamed Ameen, Thomas S Denney and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Guideline
  2. Image-Guided Cardiac Regeneration via a 3D Bioprinted Vascular Patch with Built-in CT Visibility.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2025
    Article
  3. Progress in Bioengineering Strategies for Heart Regenerative Medicine.International journal of molecular sciences · 2022
    Review
  4. Review
  5. Review
  6. Cardiac Tissue Engineering for the Treatment of Myocardial Infarction.Journal of cardiovascular development and disease · 2021
    Review
  7. Article
  8. Review
  9. Magnetic Resonance Imaging of Contracting Ultrathin Cardiac Tissue.Biomedical physics & engineering express · 2019
    Article
  10. Review
  11. Article
  12. Imaging the Cardiac Extracellular Matrix.Advances in experimental medicine and biology · 2018
    Review
  13. Remuscularization of the failing heart.The Journal of physiology · 2017
    Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Xulei QinFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Johannes RieglerFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Malte TiburcyFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Xin ZhaoFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Tony ChourFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Babacar NdoyeFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Michael NguyenFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Jackson AdamsFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Mohamed AmeenFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Thomas S DenneyFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Phillip C YangFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Patricia NguyenFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Wolfram H ZimmermannFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.).
Joseph C WuFrom the Stanford Cardiovascular Institute and Department of Medicine, Division of Cardiology, CA (X.Q., J.R., X.Z., T.C., B.N., M.N., J.A., M.A., P.C.Y., P.N., J.C.W.); Auburn University MRI Research Center, Department of Electrical and Computer Engineering, AL (T.S.D.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., W.H.Z.). joewu@stanford.edu.
Auburn University · US

Funding

Progenitor Cell Biology Consortium Administrative Coordinating CenterU01HL099997 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2009 to 2015
$29.9M
Induced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2M
Multi-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3M
Molecular Imaging of Cardiac Pluripotent Stem CellsR01HL133272 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2016 to 2020
$2.4M
Assessment of Low-Dose Radiation Risk and Mechanisms of Individual RadiosensitivityR01HL132875 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL132875NHLBI NIH HHS R01 HL133272NHLBI NIH HHS U01 HL099776NHLBI NIH HHS U01 HL099997NIBIB NIH HHS T32 EB009035
6 · The paper itself

Abstract

backgroundThe use of tissue engineering approaches in combination with exogenously produced cardiomyocytes offers the potential to restore contractile function after myocardial injury. However, current techniques assessing changes in global cardiac performance after such treatments are plagued by relatively low detection ability. Since the treatment is locally performed, this detection could be improved by myocardial strain imaging that measures regional contractility. METHODS AND

resultsTissue engineered heart muscles (EHMs) were generated by casting human embryonic stem cell-derived cardiomyocytes with collagen in preformed molds. EHMs were transplanted (n=12) to cover infarct and border zones of recipient rat hearts 1 month after ischemia reperfusion injury. A control group (n=10) received only sham placement of sutures without EHMs. To assess the efficacy of EHMs, magnetic resonance imaging and ultrasound-based strain imaging were performed before and 4 weeks after transplantation. In addition to strain imaging, global cardiac performance was estimated from cardiac magnetic resonance imaging. Although no significant differences were found for global changes in left ventricular ejection fraction (control -9.6±1.3% versus EHM -6.2±1.9%; P=0.17), regional myocardial strain from tagged magnetic resonance imaging was able to detect preserved systolic function in EHM-treated animals compared with control (control 4.4±1.0% versus EHM 1.0±0.6%; P=0.04). However, ultrasound-based strain failed to detect any significant change (control 2.1±3.0% versus EHM 6.3±2.9%; P=0.46).

conclusionsThis study highlights the feasibility of using cardiac strain from tagged magnetic resonance imaging to assess functional changes in rat models following localized regenerative therapies, which may not be detected by conventional measures of global systolic performance.

Indexed as

Cell DifferentiationMagnetic Resonance Imaging, CineMyocardial ContractionRegenerationTissue ScaffoldsAnimalsBiomechanical PhenomenaCell LineDisease Models, AnimalEchocardiographyFeasibility StudiesHeterograftsHuman Embryonic Stem CellsHumansMaleMyocardial Infarctionengineered heart musclemagnetic resonance imagingmyocardial infarctionstem cellstrain imagingtissue engineeringultrasound

Identifiers

PMID27903535
PMCPMC5378466
OpenAlexW2892647691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.