Evidence map›Paper›PMID 27903532›Full record

ArticleBlood2017

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.

Marcus A F Corat, Heinrich Schlums, Chuanfeng Wu, Jakob Theorell, Diego A Espinoza, Stephanie E Sellers, Danielle M Townsley, Neal S Young, Yenan T Bryceson, Cynthia E Dunbar and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  6. Natural Killer Cell-Based Immunotherapy against Glioblastoma.International journal of molecular sciences · 2023
    Review
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  13. Article
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  15. Article
  16. Article
  17. Article
  18. Review
  19. NK cells for cancer immunotherapy.Nature reviews. Drug discovery · 2020
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Marcus A F CoratHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Heinrich SchlumsCenter for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; and.
Chuanfeng WuHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Jakob TheorellCenter for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; and.
Diego A EspinozaHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Stephanie E SellersHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Danielle M TownsleyHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Neal S YoungHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Yenan T BrycesonCenter for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; and.
Cynthia E DunbarHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Thomas WinklerHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
National Institutes of Health · USNational Heart Lung and Blood Institute · USKarolinska University Hospital · SEUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Bergen · NO

Funding

Pathogenesis And Treatment Of Aplastic AnemiaZIAHL002315 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI YOUNG, NEAL S · 2009 to 2025
$60.1M
Telomeres DiseasesZIAHL006089 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI YOUNG, NEAL S · 2010 to 2025
$26.2M
Understanding hematopoietic stem cell mobilization and engraftmentZIAHL006063 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DUNBAR, CYNTHIA E · 2010 to 2025
$23.5M
Novel therapies for bone marrow failure and Diamond-Blackfan AnemiaZIAHL006186 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DUNBAR, CYNTHIA E · 2014 to 2025
$5.7M
6 · The paper itself

Abstract

Natural killer (NK) cells have long been considered short-lived effectors of innate immunity. However, recent animal models and human studies suggest that subsets of NK cells have adaptive features. We investigate clonal relationships of various NK-cell subsets, including the adaptive population, by taking advantage of naturally occurring X-linked somatic

Indexed as

Hemoglobinuria, ParoxysmalMembrane ProteinsAdultAgedCD56 AntigenFemaleGene Expression RegulationHematopoietic Stem CellsHumansKiller Cells, NaturalKruppel-Like Transcription FactorsMaleMiddle AgedOligosaccharidesPromyelocytic Leukemia Zinc Finger Protein(6-O-aminoethylphosphonato-mannopyranosyl)-(1-2)-mannopyranosyl-(1-6)-mannopyranosyl-(1-4)-(2-amino-2-deoxyglucopyranosyl)-(1-6)-1-O-(1,2-di-O-octadecanoyl-sn-glyceryl-phosphonato)-myo-inositolCD56 AntigenKruppel-Like Transcription FactorsMembrane ProteinsNCAM1 protein, humanOligosaccharidesphosphatidylinositol glycan-class A proteinPromyelocytic Leukemia Zinc Finger ProteinZBTB16 protein, human

Identifiers

PMID27903532
PMCPMC5383870
OpenAlexW2559448876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.