Evidence map›Paper›PMID 27903301›Full record

ArticleParasites & vectors2016

High prevalence of Strongyloides stercoralis in school-aged children in a rural highland of north-western Ethiopia: the role of intensive diagnostic work-up.

Aranzazu Amor, Esperanza Rodriguez, José M Saugar, Ana Arroyo, Beatriz López-Quintana, Bayeh Abera, Mulat Yimer, Endalew Yizengaw, Derejew Zewdie, Zimman Ayehubizu and 8 more

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 8 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 8 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Aranzazu AmorNational Center of Tropical Medicine, Institute of Health Carlos III, Madrid, Spain. aranchazu@gmail.com.
Esperanza RodriguezParasitology Service, National Centre for Microbiology, Institute of Health Carlos III, Madrid, Spain.
José M SaugarParasitology Service, National Centre for Microbiology, Institute of Health Carlos III, Madrid, Spain.
Ana ArroyoService of Microbiology and Parasitology, Hospital La Paz-Carlos III, Madrid, Spain.
Beatriz López-QuintanaService of Microbiology and Parasitology, Hospital La Paz-Carlos III, Madrid, Spain.
Bayeh AberaDepartment of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Mulat YimerDepartment of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Endalew YizengawDepartment of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Derejew ZewdieDepartment of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Zimman AyehubizuDepartment of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Tadesse HailuDepartment of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Wondemagegn MuluDepartment of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Adriana EchazúInstituto de Investigaciones en Enfermedades Tropicales, Universidad Nacional de Salta, sede regional Orán, San Ramón de la Nueva Orán, Salta, Argentina.
Alejandro J KrolewiekiInstituto de Investigaciones en Enfermedades Tropicales, Universidad Nacional de Salta, sede regional Orán, San Ramón de la Nueva Orán, Salta, Argentina.
Pilar AparicioNational School of Health, Institute of health Carlos III, Madrid, Spain.
Zaida HerradorNational Center of Tropical Medicine, Institute of Health Carlos III, Madrid, Spain.
Melaku AnegagrieNational Center of Tropical Medicine, Institute of Health Carlos III, Madrid, Spain.
Agustín BenitoNational Center of Tropical Medicine, Institute of Health Carlos III, Madrid, Spain.
Bahir Dar University · ETInstituto de Salud Carlos III · ESCentro Nacional de Medicina Tropical · ESHospital Universitario La Paz · ESNational University of Salta · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSoil-transmitted helminthiases (hookworms, Ascaris lumbricoides and Trichuris trichiura) are extremely prevalent in school-aged children living in poor sanitary conditions. Recent epidemiological data suggest that Strongyloides stercoralis is highly unreported. However, accurate data are essential for conducting interventions aimed at introducing control and elimination programmes.

methodsWe conducted a cross-sectional survey of 396 randomly selected school-aged children in Amhara region in rural area in north-western Ethiopia, to assess the prevalence of S. stercoralis and other intestinal helminths. We examined stools using three techniques: conventional stool concentration; and two S. stercoralis-specific methods, i.e. the Baermann technique and polymerase chain reaction. The diagnostic accuracy of these three methods was then compared.

resultsThere was an overall prevalence of helminths of 77.5%, with distribution differing according to school setting. Soil-transmitted helminths were recorded in 69.2%. Prevalence of S. stercoralis and hookworm infection was 20.7 and 54.5%, respectively, and co-infection was detected in 16.3% of cases. Schistosoma mansoni had a prevalence of 15.7%. Prevalence of S. stercoralis was shown 3.5% by the conventional method, 12.1% by the Baermann method, and 13.4% by PCR, which thus proved to be the most sensitive.

conclusionsOur results suggest that S. stercoralis could be overlooked and neglected in Ethiopia, if studies of soil-transmitted helminths rely on conventional diagnostic techniques alone. A combination of molecular and stool microscopy techniques yields a significantly higher prevalence. In view of the fact that current control policies for triggering drug administration are based on parasite prevalence levels, a comprehensive diagnostic approach should instead be applied to ensure comprehensive control of helminth infections.

Indexed as

AdolescentAgedAnimalsChildChild, PreschoolCoinfectionCross-Sectional StudiesEthiopiaFecesFemaleHelminthiasisHumansIntestinal Diseases, ParasiticMalePrevalenceRural PopulationBaermann techniqueEthiopiaMolecular techniquesNeglectedSoil-transmitted helminthsStrongyloides stercoralis

Identifiers

PMID27903301
PMCPMC5131444
OpenAlexW2558144866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.