ArticleBMC geriatrics2016
Gender differences in the association between grip strength and mortality in older adults: results from the KORA-age study.
Article in BMC geriatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The handgrip strength and risk of depressive symptoms: a meta-analysis of prospective cohort studies.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Pooled it
- Prevalence of posttraumatic arthritis and the association with outcome measures following distal radius fractures in non-osteoporotic patients: a systematic review.Archives of orthopaedic and trauma surgery · 2017Pooled it
- Contribution of Sport Type to the Association Between Handgrip Strength and Morbidity/Mortality: Future Follow-up Study and Possible Mechanisms.Sports medicine - open · 2026Review
- Combined Measure of Hand Grip Strength and Body Mass Index for Predicting Excess Body Fat in a University Population in Kentucky, USA.Diagnostics (Basel, Switzerland) · 2026Article
- Sex differences in major postoperative morbidity after elective abdominal surgery: independent of chronological age, frailty, and muscle strength in adjusted analysis.Aging clinical and experimental research · 2026Article
- Effects of Multicomponent Versus Aerobic Training on Body Composition, Physical Fitness, Psychological Health, and Quality of Life in Cancer Survivors: A 24-Week Randomized Controlled Trial.Sports (Basel, Switzerland) · 2026Article
- Angiotensin-Converting Enzyme Inhibitors and Metabolic Aging: A Drosophila Perspective.Biomolecules · 2025Review
- Muscle strength and mass as predictors of pancreatic cancer: insights from the UK biobank.BMC cancer · 2025Article
- Rate of force development in ankle extensors correlates with performance on functional tests that demand speed and power in older women.European journal of applied physiology · 2025Article
- Biological Sex and the Association Between Grip Strength and Cardiovascular Disease: a Scoping Review.Canadian geriatrics journal : CGJ · 2025Review
- Comparison of grip strength measurements for predicting all-cause mortality among adults aged 20+ years from the NHANES 2011-2014.Scientific reports · 2024Article
- Hand-grip strength in recreational downhill skiers: a comparison to normative reference values.European journal of translational myology · 2024Article
- Comparison between grip strength and relative grip strength in their relationship with allostatic load among adolescents.BMC public health · 2024Article
- Handgrip strength is associated with cognitive function in older patients with stage 3-5 chronic kidney disease: results from the NHANES.Scientific reports · 2024Article
- Hand grip strength as a proposed new vital sign of health: a narrative review of evidences.Journal of health, population, and nutrition · 2024Review
- An examination of the validity of neuropsychological and physical testing batteries in Latin-American adults aged over 55 years.Aging clinical and experimental research · 2023Article
- Biological ageing and the risk of decreased handgrip strength among community-dwelling older adult Indians: a cross-sectional study.BMC geriatrics · 2023Article
- High Frequency of Osteophytes Detected by High-Resolution Ultrasound at the Finger Joints of Asymptomatic Factory Workers.Journal of personalized medicine · 2023Article
- Grip strength differences in middle-aged and older adults and individuals with stroke.European journal of physical and rehabilitation medicine · 2023Observational
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Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReduced muscular strength in the old age is strongly related to activity impairment and mortality. However, studies evaluating the gender-specific association between muscularity and mortality among older adults are lacking. Thus, the objective of the present study was to examine gender differences in the association between muscular strength and mortality in a prospective population-based cohort study.
methodsData used in this study derived from the Cooperative Health Research in the Region of Augsburg (KORA)-Age Study. The present analysis includes 1,066 individuals (mean age 76 ± 11 SD years) followed up over 3 years. Handgrip strength was measured using the Jamar Dynamometer. A Cox proportional hazard model was used to determine adjusted hazard ratios of mortality with 95% confidence intervals (95% CI) for handgrip strength. Potential confounders (i.e. age, nutritional status, number of prescribed drugs, diseases and level of physical activity) were pre-selected according to evidence-based information.
resultsDuring the follow-up period, 56 men (11%) and 39 women (7%) died. Age-adjusted mortality rates per 1,000 person years (95% CI) were 77 (59-106), 24 (13-41) and 14 (7-30) for men and 57 (39-81), 14 (7-27) and 1 (0-19) for women for the first, second and third sex-specific tertile of muscular strength, respectively. Low handgrip strength was significantly associated with all-cause mortality among older men and women from the general population after controlling for significant confounders. Hazard ratios (95% CI) comparing the first and second tertile to the third tertle were 3.33 (1.53-7.22) and 1.42 (0.61-3.28), respectively. Respective hazard ratios (95% CI) for mortality were higher in women than in men ((5.23 (0.67-40.91) and 2.17 (0.27-17.68) versus 2.36 (0.97-5.75) and 0.97 (0.36-2.57)).
conclusionsGrip strength is inversely associated with mortality risk in older adults, and this association is independent of age, nutritional status, number of prescribed drugs, number of chronic diseases and level of physical activity. The association between muscular strength and all-cause mortality tended to be stronger in women. It seems to be particularly important for the weakest to enhance their levels of muscular strength in order to reduce the risk of dying early.
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