Evidence map›Paper›PMID 27903150›Full record

ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2016

Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment.

Michaela A Onstad, Rosemarie E Schmandt, Karen H Lu

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 353 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
353citing papers in PubMed, 12 pooled it
24.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04789694 phase3recruitingnot on this mapstarted 2021, after this paper: background citation

Prehabilitation in Patients With Gynaecological Cancer Planned for Postponed Surgical Management: A Prospective Randomised Trial.

TypeinterventionalSponsorCharles University, Czech RepublicRan2021 to 2026Enrolled64ConditionsOvarian Cancer, Ovarian Cancer Stage III, Ovarian Cancer Stage IV, Endometrial CancerArmsPhysiological intervention, Psychological intervention, Nutritional intervention
NCT06680791 recruitingnot on this mapstarted 2024, after this paper: background citation

Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors

TypeobservationalSponsorLukas VanekRan2024 to 2028Enrolled280ConditionsEndometrial Cancer, Genetic Predisposition, Risk Behavior
NCT06877572 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Enacting Active Survivorship: Implementation of Weight Management Strategies in Endometrial Cancer Survivors

Typeobservational_patient_registrySponsorUniversity of Kansas Medical CenterRan2025 to 2030Enrolled50ConditionsEndometrial Cancer Survivors, Weight Management, Early Stage Endometrial CancerArmsWeight loss with pharmacotherapy, Weight loss without pharmacotherapy
3 · Its place in the literature

Who cites it

353 citing papers in PubMed, 12 syntheses or guidelines pooled it, 607 citations in OpenAlex.

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293 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michaela A OnstadAll authors: The University of Texas MD Anderson Cancer Center, Houston, TX.
Rosemarie E SchmandtAll authors: The University of Texas MD Anderson Cancer Center, Houston, TX.
Karen H LuAll authors: The University of Texas MD Anderson Cancer Center, Houston, TX.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Targeting the PI3K Signaling Pathway in Endometrial CarcinomaP50CA098258 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BODURKA, DIANE · 2003 to 2020
$32.0M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA098258
6 · The paper itself

Abstract

In sharp contrast to many other cancer types, the incidence and mortality of endometrial cancer continue to grow. This unfortunate trend is, in no small part, a result of the worldwide obesity epidemic. More than half of endometrial cancers are currently attributable to obesity, which is recognized as an independent risk factor for this disease. In this review, we identify the molecular mechanisms by which obesity and adipose tissue contribute to the pathogenesis of endometrial cancer. We further discuss the impact of obesity on the clinical management of the disease and examine the development of rational behavioral and pharmaceutical interventions aimed at reducing endometrial cancer risk, improving cancer outcomes, and preserving fertility in an increasingly younger population of patients with endometrial cancer.

Indexed as

Adipose TissueEndometrial NeoplasmsFemaleHumansObesityRisk Factors

Identifiers

PMID27903150
PMCPMC5455320
OpenAlexW2560287982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.