Evidence map›Paper›PMID 27902946›Full record

ArticlePsychoneuroendocrinology2017

Social regulation of the lymph node transcriptome in rhesus macaques (Macaca mulatta).

K Chun, J P Capitanio, D M Lamkin, E K Sloan, J M G Arevalo, S W Cole

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. The Type I interferon antiviral gene program is impaired by lockdown and preserved by caregiving.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Review
  5. Article
  6. The Conserved Transcriptional Response to Adversity.Current opinion in behavioral sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

K ChunCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA. Electronic address: kchun@mednet.ucla.edu.
J P CapitanioCalifornia National Primate Research Center, USA; Department of Psychology, University of California, Davis, CA 95616, USA.
D M LamkinCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA; Department of Psychiatry & Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
E K SloanCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia; UCLA AIDS Institute, USA; Jonsson Comprehensive Cancer Center, USA.
J M G ArevaloCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA; Division of Hematology-Oncology, David Geffen School of Medicine, USA; Jonsson Comprehensive Cancer Center, USA; UCLA Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
S W ColeCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA; UCLA AIDS Institute, USA; Division of Hematology-Oncology, David Geffen School of Medicine, USA; Jonsson Comprehensive Cancer Center, USA; UCLA Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
University of Colorado Denver · USBlack AIDS Institute · USNeurobehavioral Systems · USUniversity of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Social Regulation of Gene Expression, SupplementR37AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2010 to 2017
$3.5M
Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph NodesR01DA024441 · NIDA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CAPITANIO, JOHN P · 2007 to 2010
$3.2M
Social regulation of pro-inflammatory monocytesR01AG043404 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2014 to 2018
$1.6M
Adrenergic regulation of tumor inflammation and metastatic disseminationR01CA160890 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLOAN, ERICA KATE · 2012 to 2016
$1.6M
Autonomic nervous system control of HIV-1 replicationR01AI052737 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2002 to 2005
$1.1M
Translational Research of Biobehavioral Mechanisms in Cancer ControlK07CA188237 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAMKIN, DONALD MICHAEL · 2015 to 2019
$766k
Social Regulation of Gene ExpressionR01AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, STEPHANIE · 2018 to 2019
$720k
NCI NIH HHS K07 CA188237NCI NIH HHS R01 CA160890NIAID NIH HHS R01 AI052737NIA NIH HHS R01 AG033590NIA NIH HHS R01 AG043404NIA NIH HHS R37 AG033590NIDA NIH HHS R01 DA024441NIH HHS P51 OD011107
6 · The paper itself

Abstract

Previous research has shown that adverse social conditions may promote a conserved transcriptional response to adversity (CTRA) involving up-regulation of proinflammatory gene expression and down-regulation of Type I interferon anti-viral genes in circulating blood cells. However, the impact of social conditions on lymphoid tissue gene regulation remains largely unexplored. This project assessed how social instability in adult male rhesus macaques (N=10, 5 in unstable, and 5 in stable social conditions) might regulate gene expression within secondary lymphoid tissue (lymph nodes; LN). Unstable social conditions down-regulated axillary LN expression of genes involved in Type I interferon anti-viral responses. Transcript origin analyses implicated monocytes and B cells as cellular mediators of these effects, and promoter-based bioinformatics analyses indicated reduced activity of AP-1, NF-κB, IRF, and CREB transcription factors within the axillary LN microenvironment. Although the current study is limited in sample size, these results suggest that social influences on immune cell gene regulation extend beyond the circulating leukocyte pool to alter generalized transcriptome profiles in secondary lymphoid tissue, and they do so in a regulatory program that resembles the pattern of antiviral inhibition previously observed in circulating leukocytes.

Indexed as

Social BehaviorAnimalsBehavior, AnimalDown-RegulationGene Expression RegulationLymph NodesMacaca mulattaMaleStress, PsychologicalTranscriptomeHealthInflammationRhesus macaqueSocial genomicsSocial stress

Identifiers

PMID27902946
PMCPMC5510871
OpenAlexW2549653026

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.