Evidence map›Paper›PMID 27902753›Full record

ArticlePloS one2016

Emphysema Distribution and Diffusion Capacity Predict Emphysema Progression in Human Immunodeficiency Virus Infection.

Janice M Leung, Andrea Malagoli, Antonella Santoro, Giulia Besutti, Guido Ligabue, Riccardo Scaglioni, Darlene Dai, Cameron Hague, Jonathon Leipsic, Don D Sin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023
    Review
  4. Chronic obstructive pulmonary disease in HIV.Expert review of respiratory medicine · 2021
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Janice M LeungCentre for Heart Lung Innovation, University of British Columbia, Vancouver, BC.
Andrea MalagoliModena HIV Metabolic Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Antonella SantoroModena HIV Metabolic Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Giulia BesuttiModena HIV Metabolic Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Guido LigabueModena HIV Metabolic Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Riccardo ScaglioniModena HIV Metabolic Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Darlene DaiPROOF Centre for Excellence, University of British Columbia, Vancouver, BC.
Cameron HagueDepartment of Radiology, University of British Columbia, Vancouver, Canada.
Jonathon LeipsicDepartment of Radiology, University of British Columbia, Vancouver, Canada.
Don D SinCentre for Heart Lung Innovation, University of British Columbia, Vancouver, BC.
Sf Paul ManCentre for Heart Lung Innovation, University of British Columbia, Vancouver, BC.
Giovanni GuaraldiModena HIV Metabolic Clinic, University of Modena and Reggio Emilia, Modena, Italy.
University of Modena and Reggio Emilia · ITUniversity of British Columbia · CAPrevention of Organ Failure · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) and emphysema are common amongst patients with human immunodeficiency virus (HIV). We sought to determine the clinical factors that are associated with emphysema progression in HIV.

methods345 HIV-infected patients enrolled in an outpatient HIV metabolic clinic with ≥2 chest computed tomography scans made up the study cohort. Images were qualitatively scored for emphysema based on percentage involvement of the lung. Emphysema progression was defined as any increase in emphysema score over the study period. Univariate analyses of clinical, respiratory, and laboratory data, as well as multivariable logistic regression models, were performed to determine clinical features significantly associated with emphysema progression.

results17.4% of the cohort were emphysema progressors. Emphysema progression was most strongly associated with having a low baseline diffusion capacity of carbon monoxide (DLCO) and having combination centrilobular and paraseptal emphysema distribution. In adjusted models, the odds ratio (OR) for emphysema progression for every 10% increase in DLCO percent predicted was 0.58 (95% confidence interval [CI] 0.41-0.81). The equivalent OR (95% CI) for centrilobular and paraseptal emphysema distribution was 10.60 (2.93-48.98). Together, these variables had an area under the curve (AUC) statistic of 0.85 for predicting emphysema progression. This was an improvement over the performance of spirometry (forced expiratory volume in 1 second to forced vital capacity ratio), which predicted emphysema progression with an AUC of only 0.65.

conclusionCombined paraseptal and centrilobular emphysema distribution and low DLCO could identify HIV patients who may experience emphysema progression.

Indexed as

Disease ProgressionCohort StudiesDiffusionEmphysemaFemaleHIV InfectionsHumansLogistic ModelsMaleMiddle AgedPrognosisROC CurveTomography, X-Ray Computed

Identifiers

PMID27902753
PMCPMC5130231
OpenAlexW2558375389

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.