ArticlePloS one2016
Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers.Translational psychiatry · 2025Article
- Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort.Translational psychiatry · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.medRxiv : the preprint server for health sciences · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.Frontiers in psychiatry · 2025Article
- Adolescent chronic sleep restriction promotes alcohol drinking in adulthood: evidence from epidemiological and preclinical data.bioRxiv : the preprint server for biology · 2024Article
- Molecular Alterations Caused by Alcohol Consumption in the UK Biobank: A Mendelian Randomisation Study.Nutrients · 2022Article
- Elevated emotion reactivity and emotion regulation in individuals at clinical high risk for developing psychosis and those diagnosed with a psychotic disorder.Early intervention in psychiatry · 2022Article
- DNA methylation-based predictors of health: applications and statistical considerations.Nature reviews. Genetics · 2022Review
- Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.Brain sciences · 2021Article
- Dimensions of Craving Interact withBrain sciences · 2021Article
- Risk and resilience for alcohol use disorder revealed in brain functional connectivity.NeuroImage. Clinical · 2021Article
- The causal web of foetal alcohol spectrum disorders: a review and causal diagram.European child & adolescent psychiatry · 2020Review
- Evidence That Emmetropization Buffers Against Both Genetic and Environmental Risk Factors for Myopia.Investigative ophthalmology & visual science · 2020Article
- Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers: Behavioral, Neural and Polygenic Correlates.Journal of clinical medicine · 2019Article
- A commonly occurring genetic variant within the NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of strabismus.Human genetics · 2019Article
- The Genetic Relationship Between Alcohol Consumption and Aspects of Problem Drinking in an Ascertained Sample.Alcoholism, clinical and experimental research · 2019Article
- Potential use of clinical polygenic risk scores in psychiatry - ethical implications and communicating high polygenic risk.Philosophy, ethics, and humanities in medicine : PEHM · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundUncertainty remains about the true extent by which alcohol consumption causes a number of health outcomes. Genetic variants, or combinations of variants built into a polygenic risk score (PGRS), can be used in an instrumental variable framework to assess causality between a phenotype and disease outcome of interest, a method known as Mendelian randomisation (MR). We aimed to identify genetic variants involved in the aetiology of alcohol consumption, and develop a PGRS for alcohol.
methodsRepeated measures of alcohol consumption from mothers and their offspring were collected as part of the Avon Longitudinal Study of Parents and Children. We tested the association between 89 SNPs (identified from either published GWAS data or from functional literature) and repeated measures of alcohol consumption, separately in mothers (from ages 28-48) and offspring (from ages 15-21) who had ever reported drinking. We modelled log units of alcohol using a linear mixed model and calculated beta coefficients for each SNP separately. Cross-validation was used to determine an allelic score for alcohol consumption, and the AVENGEME algorithm employed to estimate variance of the trait explained.
resultsFollowing correction for multiple testing, one SNP (rs1229984) showed evidence for association with alcohol consumption (β = -0.177, SE = 0.042, p = <0.0001) in the mothers. No SNPs showed evidence for association in the offspring after correcting for multiple testing. The optimal allelic score was generated using p-value cut offs of 0.5 and 0.05 for the mothers and offspring respectively. These scores explained 0.3% and 0.7% of the variance.
conclusionOur PGRS explains a modest amount of the variance in alcohol consumption and larger sample sizes would be required to use our PGRS in an MR framework.
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